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• W2110141337 abstract "ABSTRACT Activation of the innate immune system by bacterial DNA and DNA of other invertebrates represents a pathogen recognition mechanism. In this study we investigated macrophage responses to DNA from the intestinal protozoan parasite Entamoeba histolytica . E. histolytica genomic DNA was purified from log-phase trophozoites and tested with the mouse macrophage cell line RAW 264.7. RAW cells treated with E. histolytica DNA demonstrated an increase in levels of tumor necrosis factor alpha (TNF-α) mRNA and protein production. TNF-α production was blocked by pretreatment with chloroquine or monensin. In fact, an NF-κB luciferase reporter assay in HEK cells transfected with human TLR9 demonstrated that E. histolytica DNA signaled through Toll-like receptor 9 (TLR9) in a manner similar to that seen with CpG-ODN. Immunofluorescence assays confirmed NF-κB activation in RAW cells, as seen by nuclear translocation of the p65 subunit. Western blot analysis demonstrated mitogen-activated protein kinase activation by E. histolytica DNA. E. histolytica DNA effects were abolished in MYD88 −/− mouse-derived macrophages. In the context of disease, immunization with E. histolytica DNA protected gerbils from an E. histolytica challenge infection. Taken together, these results demonstrate that E. histolytica DNA is recognized by TLR9 to activate macrophages and may provide an innate defense mechanism characterized by the induction of the inflammatory mediator TNF-α." @default.
• W2110141337 created "2016-06-24" @default.
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• W2110141337 creator A5078279956 @default.
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• W2110141337 date "2008-01-01" @default.
• W2110141337 modified "2023-09-28" @default.
• W2110141337 title "Toll-Like Receptor 9-Dependent Macrophage Activation by<i>Entamoeba histolytica</i>DNA" @default.
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• W2110141337 doi "https://doi.org/10.1128/iai.01217-07" @default.
• W2110141337 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2223673" @default.
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