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- W2110143478 abstract "Abstract Fetal hemoglobin was studied in endogenous colonies produced in plasma clot and methylcellulose cultures of circulating progenitors from patients with polycythemia vera (PV). Analysis of globin chain synthesis showed that gamma chains constituted from 13% to 42% of the non-alpha chains produced in cultured cells, whereas from 27% to over 50% of the endogenous colonies contained Hb F, as indicated by the fluorescent antibody probe. Since the endogenous colonies in PV cultures originate from the abnormal PV clone, the findings provide direct evidence that a single pluripotent stem cell can have committed progeny that differ in their expressions of the Hb F production program." @default.
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- W2110143478 date "1979-03-01" @default.
- W2110143478 modified "2023-09-28" @default.
- W2110143478 title "Hb F production of endogenous colonies of polycythemia vera" @default.
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- W2110143478 doi "https://doi.org/10.1182/blood.v53.3.446.446" @default.
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