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- W2110147009 abstract "In Brief Purpose: To evaluate the antiproliferative effect of an all-trans retinoic acid (at-RA) drug delivery system (DDS) on experimental proliferative vitreoretinopathy (PVR). Methods: PVR was induced in rabbits with core vitrectomy and fibroblast injection. The DDS containing 420 μg, 650 μg, and 1,070 μg of at-RA was implanted into the vitreous of treated groups B, C, and D, respectively. Group A with no DDS and group E with nonmedicated DDS served as controls. The intravitreal at-RA concentration was measured with high-pressure liquid chromatography. The drug toxicity was evaluated histologically. Results: The severity of PVR was significantly reduced in groups C and D but not in groups A, B, and E. The drug release peaked at 6 weeks to 7 weeks. No signs of retinal toxicity were found in the DDS groups. Conclusion: Intravitreal implantation of at-RA DDS appears effective in inhibiting the development of PVR and is well tolerated in rabbit eyes. An all-trans retinoic acid drug delivery system implanted into the vitreous appears effective in inhibiting the development of proliferative vitreoretinopathy and is well tolerated in rabbit eyes." @default.
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- W2110147009 date "2006-02-01" @default.
- W2110147009 modified "2023-09-27" @default.
- W2110147009 title "PREVENTION OF EXPERIMENTAL PROLIFERATIVE VITREORETINOPATHY WITH A BIODEGRADABLE INTRAVITREAL DRUG DELIVERY SYSTEM OF ALL-TRANS RETINOIC ACID" @default.
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- W2110147009 doi "https://doi.org/10.1097/00006982-200602000-00015" @default.
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