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• W2110147488 abstract "Astrocytes exhibit a form of excitability based on variations of intracellular Ca2+ concentration in response to various stimuli, including ADP, ATP, UTP and dinucleotides. Here, we investigate the presence of the recently cloned ADP-sensitive receptors, P2Y12 and P2Y13 subtypes, which are negatively coupled to adenylate cyclase, in cerebellar astrocytes. We checked the effect of specific agonists, 2-methylthioadenosine diphosphate (2MeSADP) and ADP, on adenylate cyclase stimulation induced by isoproterenol. Both agonists significantly reduced the cAMP accumulation induced by isoproterenol. The inhibitory effect was concentration-dependent with IC50 values of 46 ± 13 and 23 ± 14 nM for 2MeSADP and ADP, respectively. The experiments were carried out in the presence of MRS-2179, a specific antagonist of P2Y1 receptor, to avoid any contribution of this receptor. Using fura-2 microfluorimetry we also proved that astrocytes responded to 2MeSADP stimulations with calcium responses in the absence and also in the presence of MRS-2179. Both effects, inhibition of adenylate cyclase and intracellular calcium mobilization, were not modified by 2MeSAMP, an antagonist of P2Y12 receptor, suggesting that were mediated by P2Y13-like receptors." @default.
• W2110147488 created "2016-06-24" @default.
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• W2110147488 date "2005-03-07" @default.
• W2110147488 modified "2023-09-30" @default.
• W2110147488 title "Cerebellar astrocytes co-express several ADP receptors. Presence of functional P2Y13-like receptors" @default.
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• W2110147488 doi "https://doi.org/10.1007/s11302-005-6211-3" @default.
• W2110147488 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2096534" @default.
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