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• W2110152291 startingPage "2499" @default.
• W2110152291 abstract "ABSTRACT The human pathogen enterohemorrhagic Escherichia coli (EHEC) O157:H7 codes for two interacting DNA binding proteins, Cra and KdpE, that coregulate expression of the locus of enterocyte effacement (LEE) genes in a metabolite-dependent manner. Cra is a transcription factor that uses fluctuations in the concentration of carbon metabolism intermediates to positively regulate virulence of EHEC. KdpE is a response regulator that activates the transcription of homeostasis genes in response to salt-induced osmolarity and virulence genes in response to changes in metabolite concentrations. Here, we probed the transcriptional profiles of the Δ cra , Δ kdpE , and Δ cra Δ kdpE mutant strains and show that Cra and KdpE share several targets besides the LEE, but both Cra and KdpE also have independent targets. Several genes within O-islands (genomic islands present in EHEC but absent from E. coli K-12), such as Z0639 , Z0640 , Z3388 , Z4267 , and espFu (encoding an effector necessary for formation of attaching and effacing lesions on epithelial cells), were directly regulated by both Cra and KdpE, while Z2077 was only regulated by Cra. These studies identified and confirmed new direct targets for Cra and KdpE that included putative virulence factors as well as characterized virulence factors, such as EspFu and EspG. These results map out the role of the two interacting regulators, Cra and KdpE, in EHEC pathogenesis and global gene regulation." @default.
• W2110152291 created "2016-06-24" @default.
• W2110152291 creator A5026041318 @default.
• W2110152291 creator A5027665615 @default.
• W2110152291 creator A5027984034 @default.
• W2110152291 date "2013-06-01" @default.
• W2110152291 modified "2023-10-16" @default.
• W2110152291 title "The Interacting Cra and KdpE Regulators Are Involved in the Expression of Multiple Virulence Factors in Enterohemorrhagic Escherichia coli" @default.
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• W2110152291 cites W1572646932 @default.
• W2110152291 cites W1602731345 @default.
• W2110152291 cites W1671978125 @default.
• W2110152291 cites W1837334211 @default.
• W2110152291 cites W1868993240 @default.
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• W2110152291 doi "https://doi.org/10.1128/jb.02252-12" @default.
• W2110152291 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3676075" @default.
• W2110152291 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23524613" @default.
• W2110152291 hasPublicationYear "2013" @default.
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