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• W2110153008 abstract "The two Caenorhabditis elegans gustatory neurons, ASE left (ASEL) and ASE right (ASER) are morphologically bilaterally symmetric, yet left/right asymmetric in function and in the expression of specific chemosensory signaling molecules. The ASEL versus ASER cell-fate decision is controlled by a complex gene regulatory network composed of microRNAs (miRNAs) and transcription factors. Alterations in the activities of each of these regulatory factors cause a complete lateral cell-fate switch. Here, we describe lsy-2, a novel C2H2 zinc finger transcription factor that is required for the execution of the ASEL stable state. In lsy-2 null mutants, the ASEL neuron adopts the complete ASER gene expression profile, including both upstream regulatory and terminal effector genes. The normally left/right asymmetric ASE neurons are therefore ;symmetrized' in lsy-2 mutants. Cell-specific rescue experiments indicate that lsy-2 is required autonomously in ASEL for the activation of ASEL-specifying factors and the repression of ASER-specifying factors. Genetic epistasis experiments demonstrate that lsy-2 exerts its activity by regulating the transcription of the lsy-6 miRNA in the ASEL neuron, thereby making lsy-2 one of the few factors known to control the cell-type specificity of miRNA gene expression." @default.
• W2110153008 created "2016-06-24" @default.
• W2110153008 creator A5041472770 @default.
• W2110153008 creator A5085275965 @default.
• W2110153008 date "2005-12-15" @default.
• W2110153008 modified "2023-10-01" @default.
• W2110153008 title "A novel <i>C. elegans</i> zinc finger transcription factor, <i>lsy-2</i>, required for the cell type-specific expression of the <i>lsy-6</i> microRNA" @default.
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• W2110153008 doi "https://doi.org/10.1242/dev.02163" @default.
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