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- W2110155388 abstract "The importance of tumor microenvironmental in malignant progression has been largely ignored. Tumor cells protect themselves from changes in the microenvironment due to a decrease in nutrients and oxygen by reducing macromolecular synthesis and inducing genes that will promote angiogenesis and tissue remodeling. This ability of transformed cells to survive fluctuations in oxygen tensions is clinically important, as tumors with high hypoxic fractions respond poorly to many forms of cancer therapy. While it is commonly accepted that the decrease in molecular oxygen in hypoxic cells makes them more refractory to killing by agents such as ionizing radiation which use oxygen radical formation, the cessation of division and loss of apoptotic (cell suicide) potential in hypoxic cells are also important in their resistance to killing by radiotherapy and chemotherapy. In this chapter, we will discuss hypoxia-induced stress proteins in regards to three clinically relevant end points: inhibition of cell proliferation, induced of apoptosis, and regulation of genes modulating angiogenesis. Although these three end points may seem unrelated, in fact, they are intimately linked with each other in the cellular response to hypoxia and malignant progression. One of the goals of this review is to inform both clinician and scientist of these interrelationships and discuss how hypoxia selects for tumors that are clonal expansions of cells that have lost their apoptotic ability and have switched to a proangiogenic phenotype." @default.
- W2110155388 created "2016-06-24" @default.
- W2110155388 creator A5080172191 @default.
- W2110155388 date "1996-01-01" @default.
- W2110155388 modified "2023-09-25" @default.
- W2110155388 title "Hypoxic stress proteins: Survival of the fittest" @default.
- W2110155388 cites W1494401713 @default.
- W2110155388 cites W1503667331 @default.
- W2110155388 cites W1517952165 @default.
- W2110155388 cites W1550656265 @default.
- W2110155388 cites W1558614105 @default.
- W2110155388 cites W1637596780 @default.
- W2110155388 cites W1799140375 @default.
- W2110155388 cites W1831319429 @default.
- W2110155388 cites W1835998150 @default.
- W2110155388 cites W1965094170 @default.
- W2110155388 cites W1970311855 @default.
- W2110155388 cites W1972438151 @default.
- W2110155388 cites W1976999762 @default.
- W2110155388 cites W1979319210 @default.
- W2110155388 cites W1984235414 @default.
- W2110155388 cites W1985789519 @default.
- W2110155388 cites W1987656388 @default.
- W2110155388 cites W1988840026 @default.
- W2110155388 cites W1988939915 @default.
- W2110155388 cites W1989936068 @default.
- W2110155388 cites W1995496245 @default.
- W2110155388 cites W2000894432 @default.
- W2110155388 cites W2001375090 @default.
- W2110155388 cites W2001586358 @default.
- W2110155388 cites W2001977989 @default.
- W2110155388 cites W2003282728 @default.
- W2110155388 cites W2005546492 @default.
- W2110155388 cites W2005677707 @default.
- W2110155388 cites W2008301561 @default.
- W2110155388 cites W2012851453 @default.
- W2110155388 cites W2013330927 @default.
- W2110155388 cites W2013436421 @default.
- W2110155388 cites W2015344488 @default.
- W2110155388 cites W2017691475 @default.
- W2110155388 cites W2020795308 @default.
- W2110155388 cites W2024206845 @default.
- W2110155388 cites W2026834760 @default.
- W2110155388 cites W2033791403 @default.
- W2110155388 cites W2035746057 @default.
- W2110155388 cites W2037728125 @default.
- W2110155388 cites W2037915962 @default.
- W2110155388 cites W2038768123 @default.
- W2110155388 cites W2039653473 @default.
- W2110155388 cites W2046555195 @default.
- W2110155388 cites W2054562170 @default.
- W2110155388 cites W2060786724 @default.
- W2110155388 cites W2063852118 @default.
- W2110155388 cites W2067241300 @default.
- W2110155388 cites W2068807148 @default.
- W2110155388 cites W2070589206 @default.
- W2110155388 cites W2072489106 @default.
- W2110155388 cites W2072839085 @default.
- W2110155388 cites W2073415946 @default.
- W2110155388 cites W2073417537 @default.
- W2110155388 cites W2074339256 @default.
- W2110155388 cites W2074981528 @default.
- W2110155388 cites W2076203177 @default.
- W2110155388 cites W2078066154 @default.
- W2110155388 cites W2081894694 @default.
- W2110155388 cites W2082197167 @default.
- W2110155388 cites W2088575458 @default.
- W2110155388 cites W2114098415 @default.
- W2110155388 cites W2125297918 @default.
- W2110155388 cites W2126125019 @default.
- W2110155388 cites W2128366838 @default.
- W2110155388 cites W2133362776 @default.
- W2110155388 cites W2134313753 @default.
- W2110155388 cites W2134582008 @default.
- W2110155388 cites W2143332225 @default.
- W2110155388 cites W2145596465 @default.
- W2110155388 cites W2158743409 @default.
- W2110155388 cites W2173344695 @default.
- W2110155388 cites W2182825613 @default.
- W2110155388 cites W22520275 @default.
- W2110155388 cites W282058052 @default.
- W2110155388 cites W54722803 @default.
- W2110155388 doi "https://doi.org/10.1016/s1053-4296(96)80035-x" @default.
- W2110155388 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10717161" @default.
- W2110155388 hasPublicationYear "1996" @default.
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