Matches in SemOpenAlex for { <https://semopenalex.org/work/W2110162419> ?p ?o ?g. }
Showing items 1 to 55 of
55
with 100 items per page.
- W2110162419 abstract "The functional reproductive alterations seen in women with type 1 diabetes (T1D) have changed as therapy has improved. Historically, patients with T1D and insufficient metabolic control exhibited a high prevalence of amenorrhea, hypogonadism, and infertility. Recent publications have shown that in spite of intensive insulin therapy, some delay in the age of thelarche, pubarche and menarche is still observed in girls with T1D. In addition, ovarian hyperandrogenism may be observed during late adolescence and an increased prevalence of hirsutism and polycystic ovarian syndrome (PCOS) has been described in adult women with T1D. These endocrine abnormalities may be related to non-physiologic insulin replacement therapy and to hyperglycemia.Insulin is well known for its effects on carbohydrate metabolism, but this hormone also plays an important role in regulating ovarian function. Granulosa, theca and stromal ovarian cells may be affected by insulin deficiency or excess, which may be present in women with type 1 diabetes mellitus (T1D)[1]. Diabetes disrupts hypothalamic-pituitary-ovarian function, as documented by animal model studies which have helped to decipher the underlying basis of these conditions and have highlighted the variable contributions of defective leptin, insulin and kisspeptin signalling to the mechanisms of perturbed reproduction in T1D[2].Effects of diabetes on gonadal function vary according to the age of the patient. Young girls during adrenarche exhibit an elevation of DHEAS, androstenedione, inhibin B and anti-mullerian hormone[3], an endocrine profile that is similar to the one observed in young girls in risk of developing polycystic ovarian syndrome later in life. During puberty a delay in pubertal development has been described which is followed by menstrual irregularities and hyperandrogenism during adolescence [1,4,5]. Despite these abnormalities in ovarian function, ovulatory functions is preserved in adolescents with type 1 diabetes[6]. Later in life, adult women with type 1 diabetes exhibit PCOS, polycystic ovaries at the ultrasonographic exam, menstrual irregularities and early decline in ovarian reserve[7-9].Clearly, despite improvements in insulin therapy, T1D patients still suffer several significant clinical problems, such as pubertal delay, menstrual disturbances and hyperandrogenism which may ultimately lead to the development of PCOS in adulthood. (Fondecyt 1100123 y 1050452)" @default.
- W2110162419 created "2016-06-24" @default.
- W2110162419 creator A5000749295 @default.
- W2110162419 date "2013-10-01" @default.
- W2110162419 modified "2023-09-26" @default.
- W2110162419 title "The gonadal effects of diabetes" @default.
- W2110162419 cites W1981944612 @default.
- W2110162419 cites W2020393315 @default.
- W2110162419 cites W2033771992 @default.
- W2110162419 cites W2089057350 @default.
- W2110162419 cites W2105290217 @default.
- W2110162419 cites W2124397083 @default.
- W2110162419 cites W2163578413 @default.
- W2110162419 cites W2165646110 @default.
- W2110162419 doi "https://doi.org/10.1186/1687-9856-2013-s1-o9" @default.
- W2110162419 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3850460" @default.
- W2110162419 hasPublicationYear "2013" @default.
- W2110162419 type Work @default.
- W2110162419 sameAs 2110162419 @default.
- W2110162419 citedByCount "1" @default.
- W2110162419 countsByYear W21101624192015 @default.
- W2110162419 crossrefType "journal-article" @default.
- W2110162419 hasAuthorship W2110162419A5000749295 @default.
- W2110162419 hasBestOaLocation W21101624191 @default.
- W2110162419 hasConcept C134018914 @default.
- W2110162419 hasConcept C187212893 @default.
- W2110162419 hasConcept C512399662 @default.
- W2110162419 hasConcept C555293320 @default.
- W2110162419 hasConcept C71924100 @default.
- W2110162419 hasConceptScore W2110162419C134018914 @default.
- W2110162419 hasConceptScore W2110162419C187212893 @default.
- W2110162419 hasConceptScore W2110162419C512399662 @default.
- W2110162419 hasConceptScore W2110162419C555293320 @default.
- W2110162419 hasConceptScore W2110162419C71924100 @default.
- W2110162419 hasIssue "S1" @default.
- W2110162419 hasLocation W21101624191 @default.
- W2110162419 hasLocation W21101624192 @default.
- W2110162419 hasLocation W21101624193 @default.
- W2110162419 hasOpenAccess W2110162419 @default.
- W2110162419 hasPrimaryLocation W21101624191 @default.
- W2110162419 hasRelatedWork W1563850031 @default.
- W2110162419 hasRelatedWork W2032287785 @default.
- W2110162419 hasRelatedWork W2033269302 @default.
- W2110162419 hasRelatedWork W2094113608 @default.
- W2110162419 hasRelatedWork W2233866314 @default.
- W2110162419 hasRelatedWork W2374391052 @default.
- W2110162419 hasRelatedWork W2383009242 @default.
- W2110162419 hasRelatedWork W2415759662 @default.
- W2110162419 hasRelatedWork W3036934084 @default.
- W2110162419 hasRelatedWork W88627568 @default.
- W2110162419 hasVolume "2013" @default.
- W2110162419 isParatext "false" @default.
- W2110162419 isRetracted "false" @default.
- W2110162419 magId "2110162419" @default.
- W2110162419 workType "article" @default.