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• W2110171572 abstract "Few genes in the divergent eukaryote Trichomonas vaginalis have introns, despite the unusually large gene repertoire of this human-infective parasite. These introns are characterized by extended conserved regulatory motifs at the 5' and 3' boundaries, a feature shared with another divergent eukaryote, Giardia lamblia, but not with metazoan introns. This unusual characteristic of T. vaginalis introns led us to examine spliceosomal small nuclear RNAs (snRNAs) predicted to mediate splicing reactions via interaction with intron motifs. Here we identify T. vaginalis U1, U2, U4, U5, and U6 snRNAs, present predictions of their secondary structures, and provide evidence for interaction between the U2/U6 snRNA complex and a T. vaginalis intron. Structural models predict that T. vaginalis snRNAs contain conserved sequences and motifs similar to those found in other examined eukaryotes. These data indicate that mechanisms of intron recognition as well as coordination of the two catalytic steps of splicing have been conserved throughout eukaryotic evolution. Unexpectedly, we found that T. vaginalis spliceosomal snRNAs lack the 5' trimethylguanosine cap typical of snRNAs and appear to possess unmodified 5' ends. Despite the lack of a cap structure, U1, U2, U4, and U5 genes are transcribed by RNA polymerase II, whereas the U6 gene is transcribed by RNA polymerase III." @default.
• W2110171572 created "2016-06-24" @default.
• W2110171572 creator A5005240902 @default.
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• W2110171572 creator A5046888833 @default.
• W2110171572 creator A5054011186 @default.
• W2110171572 date "2008-06-20" @default.
• W2110171572 modified "2023-09-27" @default.
• W2110171572 title "Spliceosomal snRNAs in the unicellular eukaryote Trichomonas vaginalis are structurally conserved but lack a 5'-cap structure" @default.
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• W2110171572 doi "https://doi.org/10.1261/rna.1045408" @default.
• W2110171572 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2491460" @default.
• W2110171572 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18596255" @default.
• W2110171572 hasPublicationYear "2008" @default.
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