FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2110173014> ?p ?o ?g. }

• W2110173014 endingPage "2169" @default.
• W2110173014 startingPage "2157" @default.
• W2110173014 abstract "A microsomal, mixed function oxidase that successively N-demethylates substituted 3-(phenyl)-1,1-dimethylurea substrates was isolated from etiolated cotton seedling hypocotyl extracts by differential and density gradient centrifugation. Active enzyme preparations were also isolated from leaves of cotton, plantain, buckwheat, wild buckwheat and broadbeans. The enzyme is located in the microsomal fraction of plant extracts and requires molecular oxygen and either NADPH or NADH as cofactors. The formation of 1 mole of formaldehyde for each mole of substrate demethylated was demonstrated with 14C methyl-labeled substrate. The enzyme appears to be specific for substituted 3-(phenyl)-1-methylurea compounds, and the apparent Km values for three of these substrates were determined. Inhibition of the enzyme by carbon monoxide, ionic detergents, sulfhydryl reagents, chelating agents and electron acceptors, together with the demonstrated presence of a b5 cytochrome and an active NADPH-cytochrome c reductase, are discussed as indirect evidence for a microsomal electron transport system in plants similar to those reported for animals. Several differences between the cotton N-demethylase and similar animal systems were also noted. These differences included a greater instability and a decreased sensitivity toward the insecticidal synergists 2,2-diethylaminoethyl-2,2-diphenylpentanoate (SKF 525-A) and 2-(3,4-methylenedioxyphenoxy)-3,6,9-trioxoundecane (Sesamex). The inhibition of N-demethylase activity by several N-methylcarbamates was investigated and the apparent Ki value for the competitive inhibition by 1-naphthylmethylcarbamate was determined." @default.
• W2110173014 created "2016-06-24" @default.
• W2110173014 creator A5018552107 @default.
• W2110173014 creator A5026308080 @default.
• W2110173014 creator A5047746349 @default.
• W2110173014 date "1969-11-01" @default.
• W2110173014 modified "2023-10-18" @default.
• W2110173014 title "N-demethylation of substituted 3-(phenyl)-1-methylureas: Isolation and characterization of a microsomal mixed function oxidase from cotton" @default.
• W2110173014 cites W1506403067 @default.
• W2110173014 cites W15153607 @default.
• W2110173014 cites W1749512707 @default.
• W2110173014 cites W1775749144 @default.
• W2110173014 cites W183923560 @default.
• W2110173014 cites W1989775081 @default.
• W2110173014 cites W1990404855 @default.
• W2110173014 cites W2014383943 @default.
• W2110173014 cites W2014864340 @default.
• W2110173014 cites W2020762097 @default.
• W2110173014 cites W2042468065 @default.
• W2110173014 cites W2056251182 @default.
• W2110173014 cites W2057549491 @default.
• W2110173014 cites W2057814279 @default.
• W2110173014 cites W2061782006 @default.
• W2110173014 cites W2069499790 @default.
• W2110173014 cites W2076401275 @default.
• W2110173014 cites W2082518718 @default.
• W2110173014 cites W2087823523 @default.
• W2110173014 cites W2137226976 @default.
• W2110173014 cites W2169585799 @default.
• W2110173014 cites W2395516406 @default.
• W2110173014 cites W2528047366 @default.
• W2110173014 cites W2576838834 @default.
• W2110173014 cites W2797441441 @default.
• W2110173014 cites W2801529098 @default.
• W2110173014 cites W2947154595 @default.
• W2110173014 cites W3215323180 @default.
• W2110173014 cites W33074556 @default.
• W2110173014 doi "https://doi.org/10.1016/s0031-9422(00)88175-3" @default.
• W2110173014 hasPublicationYear "1969" @default.
• W2110173014 type Work @default.
• W2110173014 sameAs 2110173014 @default.
• W2110173014 citedByCount "150" @default.
• W2110173014 countsByYear W21101730142012 @default.
• W2110173014 countsByYear W21101730142014 @default.
• W2110173014 countsByYear W21101730142015 @default.
• W2110173014 countsByYear W21101730142016 @default.
• W2110173014 countsByYear W21101730142018 @default.
• W2110173014 countsByYear W21101730142019 @default.
• W2110173014 countsByYear W21101730142020 @default.
• W2110173014 countsByYear W21101730142021 @default.
• W2110173014 countsByYear W21101730142022 @default.
• W2110173014 countsByYear W21101730142023 @default.
• W2110173014 crossrefType "journal-article" @default.
• W2110173014 hasAuthorship W2110173014A5018552107 @default.
• W2110173014 hasAuthorship W2110173014A5026308080 @default.
• W2110173014 hasAuthorship W2110173014A5047746349 @default.
• W2110173014 hasConcept C104317684 @default.
• W2110173014 hasConcept C134651460 @default.
• W2110173014 hasConcept C150194340 @default.
• W2110173014 hasConcept C181199279 @default.
• W2110173014 hasConcept C185592680 @default.
• W2110173014 hasConcept C18903297 @default.
• W2110173014 hasConcept C190727270 @default.
• W2110173014 hasConcept C202199734 @default.
• W2110173014 hasConcept C2777289219 @default.
• W2110173014 hasConcept C2780768313 @default.
• W2110173014 hasConcept C2781364455 @default.
• W2110173014 hasConcept C38485361 @default.
• W2110173014 hasConcept C41091548 @default.
• W2110173014 hasConcept C55493867 @default.
• W2110173014 hasConcept C71240020 @default.
• W2110173014 hasConcept C86803240 @default.
• W2110173014 hasConcept C87644729 @default.
• W2110173014 hasConceptScore W2110173014C104317684 @default.
• W2110173014 hasConceptScore W2110173014C134651460 @default.
• W2110173014 hasConceptScore W2110173014C150194340 @default.
• W2110173014 hasConceptScore W2110173014C181199279 @default.
• W2110173014 hasConceptScore W2110173014C185592680 @default.
• W2110173014 hasConceptScore W2110173014C18903297 @default.
• W2110173014 hasConceptScore W2110173014C190727270 @default.
• W2110173014 hasConceptScore W2110173014C202199734 @default.
• W2110173014 hasConceptScore W2110173014C2777289219 @default.
• W2110173014 hasConceptScore W2110173014C2780768313 @default.
• W2110173014 hasConceptScore W2110173014C2781364455 @default.
• W2110173014 hasConceptScore W2110173014C38485361 @default.
• W2110173014 hasConceptScore W2110173014C41091548 @default.
• W2110173014 hasConceptScore W2110173014C55493867 @default.
• W2110173014 hasConceptScore W2110173014C71240020 @default.
• W2110173014 hasConceptScore W2110173014C86803240 @default.
• W2110173014 hasConceptScore W2110173014C87644729 @default.
• W2110173014 hasIssue "11" @default.
• W2110173014 hasLocation W21101730141 @default.
• W2110173014 hasOpenAccess W2110173014 @default.
• W2110173014 hasPrimaryLocation W21101730141 @default.
• W2110173014 hasRelatedWork W1763452050 @default.
• W2110173014 hasRelatedWork W1931472944 @default.
• W2110173014 hasRelatedWork W1965039372 @default.
• W2110173014 hasRelatedWork W1972433077 @default.

• next