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• W2110174828 abstract "Aconitine is an effective ingredient in Aconite tuber, an important traditional Chinese medicine. Aconitine is also known to be a highly toxic diterpenoid alkaloid with arrhythmogenic effects. In the present study, we have characterized the properties of arrhythmic cytotoxicity and explored the possible mechanisms of aconitine-induced cardiomyocytes. Results show that aconitine induces significant abnormity in the spontaneous beating rate, amplitude of spontaneous oscillations and the relative intracellular Ca2+ concentration. Also, mRNA transcription levels and protein expressions of SR Ca2+ release channel RyR2 and sarcolemmal NCX were elevated in aconitine-induced cardiomyocytes. However, co-treatment with ruthenium red (RR), a RyR channel inhibitor, could reverse the aconitine-induced abnormity in intracellular Ca2+ signals. These results demonstrate that disruption of intracellular Ca2+ homeostasis in the cardiac excitation–contraction coupling (EC coupling) is a crucial mechanism of arrhythmic cytotoxicity in aconitine-induced cardiomyocytes. Moreover, certain inhibitors appear to play an important role in the detoxification of aconitine-induced Ca2+-dependent arrhythmias." @default.
• W2110174828 created "2016-06-24" @default.
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• W2110174828 date "2007-03-01" @default.
• W2110174828 modified "2023-10-12" @default.
• W2110174828 title "Disruption of the intracellular Ca2+ homeostasis in the cardiac excitation–contraction coupling is a crucial mechanism of arrhythmic toxicity in aconitine-induced cardiomyocytes" @default.
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• W2110174828 doi "https://doi.org/10.1016/j.bbrc.2007.01.082" @default.
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