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- W2110184595 abstract "BackgroundType 1 regulatory T (Tr1) cells are an inducible subset ofregulatory T cells that play a pivotal role in promoting andmaintaining tolerance. The main mechanisms by whichTr1 cells control immune responses are the secretion ofhigh levels of IL-10, and the killing of myeloid myeloidcells through the release of Granzyme B. To date a definedcell surface signature has not been identified for Tr1 cellsand their characterization has thus relied on their uniquecytokine production profile. Tr1 cells secrete high levels ofIL-10 and minimal amounts of IL-4 and IL-17, which dis-tinguish them from Th2 and Th17 [1]. Furthermore, Tr1cells secrete low levels of IL-2, and depending on the localcytokine milieu can produce variable levels of IFN- g.Simi-lar to other T cell subsets, Tr1 cells can transiently expressFOXP3 upon activation; however, in Tr1 cells FOXP3expression is not constitutive and never reaches the highlevels characteristic of CD25" @default.
- W2110184595 created "2016-06-24" @default.
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- W2110184595 date "2012-11-01" @default.
- W2110184595 modified "2023-10-16" @default.
- W2110184595 title "Type 1 regulatory T (Tr1) cells: from the bench to the bedside" @default.
- W2110184595 cites W1975672348 @default.
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- W2110184595 doi "https://doi.org/10.1186/1479-5876-10-s3-i7" @default.
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