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• W2110186334 abstract "Exogenously added granulysin was reported to kill mammalian target cells. The sites of actions and molecular mechanisms of granulysin in target cell killing, however, are presently unclear. We here examine the effects of granulysin with the target HeLa cells transiently expressed with GFPfused 9 kDa granulysin. Endogenously expressed GFP-fused granulysin was preferentially localized in the nucleus and induced apoptotic cell death accompanying with phosphatidylserine translocation and nuclear condensation in a caspase-independent manner. These results suggest that granulysin enters the nucleus of target cells and induces apoptosis." @default.
• W2110186334 created "2016-06-24" @default.
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• W2110186334 date "2005-03-01" @default.
• W2110186334 modified "2023-09-24" @default.
• W2110186334 title "Granulysin induces cell death with nuclear accumulation." @default.
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• W2110186334 doi "https://doi.org/10.11480/jmds.520101" @default.
• W2110186334 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15868735" @default.
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