FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2110195338> ?p ?o ?g. }

• W2110195338 abstract "Regeneration of damaged tissues typically requires a population of active stem cells. How damaged tissue is regenerated in quiescent tissues lacking a stem cell population is less well understood. We used a genetic screen in the developing Drosophila melanogaster eye to investigate the mechanisms that trigger quiescent cells to re-enter the cell cycle and proliferate in response to tissue damage. We discovered that Hippo signaling regulates compensatory proliferation after extensive cell death in the developing eye. Scalloped and Yorkie, transcriptional effectors of the Hippo pathway, drive Cyclin E expression to induce cell cycle re-entry in cells that normally remain quiescent in the absence of damage. Ajuba, an upstream regulator of Hippo signaling that functions as a sensor of epithelial integrity, is also required for cell cycle re-entry. Thus, in addition to its well-established role in modulating proliferation during periods of tissue growth, Hippo signaling maintains homeostasis by regulating quiescent cell populations affected by tissue damage." @default.
• W2110195338 created "2016-06-24" @default.
• W2110195338 creator A5069472220 @default.
• W2110195338 creator A5089762109 @default.
• W2110195338 date "2015-01-01" @default.
• W2110195338 modified "2023-10-12" @default.
• W2110195338 title "Scalloped and Yorkie are required for cell cycle re-entry of quiescent cells after tissue damage" @default.
• W2110195338 cites W1965198388 @default.
• W2110195338 cites W1967897970 @default.
• W2110195338 cites W1968660175 @default.
• W2110195338 cites W1969244959 @default.
• W2110195338 cites W1971523031 @default.
• W2110195338 cites W1973497073 @default.
• W2110195338 cites W1978746441 @default.
• W2110195338 cites W1982397395 @default.
• W2110195338 cites W1984282087 @default.
• W2110195338 cites W1987041209 @default.
• W2110195338 cites W1987530071 @default.
• W2110195338 cites W1989382065 @default.
• W2110195338 cites W1992138103 @default.
• W2110195338 cites W1993309022 @default.
• W2110195338 cites W1996690536 @default.
• W2110195338 cites W1997905438 @default.
• W2110195338 cites W1998523488 @default.
• W2110195338 cites W2001202251 @default.
• W2110195338 cites W2001762363 @default.
• W2110195338 cites W2003769148 @default.
• W2110195338 cites W2009440283 @default.
• W2110195338 cites W2011725556 @default.
• W2110195338 cites W2012853593 @default.
• W2110195338 cites W2019621646 @default.
• W2110195338 cites W2021772999 @default.
• W2110195338 cites W2023599444 @default.
• W2110195338 cites W2024591824 @default.
• W2110195338 cites W2031101273 @default.
• W2110195338 cites W2035508405 @default.
• W2110195338 cites W2039178317 @default.
• W2110195338 cites W2046666752 @default.
• W2110195338 cites W2046930479 @default.
• W2110195338 cites W2046985565 @default.
• W2110195338 cites W2052379228 @default.
• W2110195338 cites W2053703164 @default.
• W2110195338 cites W2061058076 @default.
• W2110195338 cites W2062094940 @default.
• W2110195338 cites W2063679025 @default.
• W2110195338 cites W2066147981 @default.
• W2110195338 cites W2068989911 @default.
• W2110195338 cites W2073855688 @default.
• W2110195338 cites W2075406901 @default.
• W2110195338 cites W2078197764 @default.
• W2110195338 cites W2085197940 @default.
• W2110195338 cites W2086819694 @default.
• W2110195338 cites W2088557523 @default.
• W2110195338 cites W2090698584 @default.
• W2110195338 cites W2091621334 @default.
• W2110195338 cites W2094562654 @default.
• W2110195338 cites W2105584204 @default.
• W2110195338 cites W2111763078 @default.
• W2110195338 cites W2115095305 @default.
• W2110195338 cites W2116043679 @default.
• W2110195338 cites W2116363471 @default.
• W2110195338 cites W2117841435 @default.
• W2110195338 cites W2120729899 @default.
• W2110195338 cites W2121072573 @default.
• W2110195338 cites W2124097936 @default.
• W2110195338 cites W2125091346 @default.
• W2110195338 cites W2125421161 @default.
• W2110195338 cites W2125545718 @default.
• W2110195338 cites W2126747203 @default.
• W2110195338 cites W2131408040 @default.
• W2110195338 cites W2141204618 @default.
• W2110195338 cites W2142227317 @default.
• W2110195338 cites W2144375779 @default.
• W2110195338 cites W2144942522 @default.
• W2110195338 cites W2145170335 @default.
• W2110195338 cites W2146156306 @default.
• W2110195338 cites W2148076560 @default.
• W2110195338 cites W2148321549 @default.
• W2110195338 cites W2153267776 @default.
• W2110195338 cites W2154481751 @default.
• W2110195338 cites W2158092584 @default.
• W2110195338 cites W2168047241 @default.
• W2110195338 cites W2171501785 @default.
• W2110195338 cites W2171572099 @default.
• W2110195338 cites W2402529736 @default.
• W2110195338 cites W4241329400 @default.
• W2110195338 doi "https://doi.org/10.1242/dev.119339" @default.
• W2110195338 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4550963" @default.
• W2110195338 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26160905" @default.
• W2110195338 hasPublicationYear "2015" @default.
• W2110195338 type Work @default.
• W2110195338 sameAs 2110195338 @default.
• W2110195338 citedByCount "29" @default.
• W2110195338 countsByYear W21101953382015 @default.
• W2110195338 countsByYear W21101953382016 @default.
• W2110195338 countsByYear W21101953382017 @default.
• W2110195338 countsByYear W21101953382018 @default.
• W2110195338 countsByYear W21101953382019 @default.
• W2110195338 countsByYear W21101953382020 @default.
• W2110195338 countsByYear W21101953382021 @default.

• next