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- W2110201680 abstract "Objective To determine the feasibility and the benefits of combined resistance and interval exercise training on phenotype characteristics and skeletal muscle function in deconditioned, type 2 diabetes (T2D) patients with polyneuropathy. Design Short-term, single-arm intervention trial. Methods Eleven male T2D patients (age: 59.1±7.5 years; body mass index: 32.2±4.0 kg/m 2 ) performed progressive resistance and interval exercise training thrice a week for 10 weeks. Besides primary diabetes outcome measures, muscle strength (MUST), maximal workload capacity ( W max ), whole-body peak oxygen uptake (VO 2peak ) and muscle oxidative capacity (MUOX), intramyocellular lipid (IMCL) and glycogen (IMCG) storage, and systemic inflammation markers were determined before and after training. Daily exogenous insulin requirements (EIR) and historic individualized EIR were gathered and analysed. Results MUST and W max increased with 17% (90% confidence intervals 9–24%) and 14% (6–21) respectively. Furthermore, mean arterial blood pressure declined with 5.5 mmHg (−9.7 to −1.4). EIR dropped with 5.0 IU/d (−11.5 to 1.5) compared with baseline. A decline of respectively −0.7 mmol/l (−2.9 to 1.5) and −147 μmol/l (−296 to 2) in fasting plasma glucose and non-esterified fatty acids concentrations were observed following the intervention, but these were not accompanied by changes in VO 2peak , MUOX, IMCL or IMCG, and blood glycolysated haemoglobin, adiponectin, tumor necrosis factor-α and/or cholesterol concentrations. Conclusion Short-term resistance and interval exercise training is feasible in deconditioned T2D patients with polyneuropathy and accompanied by moderate improvements in muscle function and blood pressure. Such a specific exercise regimen may provide a better framework for future exercise intervention programmes in the treatment of deconditioned T2D patients." @default.
- W2110201680 created "2016-06-24" @default.
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- W2110201680 date "2008-02-01" @default.
- W2110201680 modified "2023-09-23" @default.
- W2110201680 title "Long-standing, insulin-treated type 2 diabetes patients with complications respond well to short-term resistance and interval exercise training" @default.
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- W2110201680 doi "https://doi.org/10.1530/eje-07-0169" @default.
- W2110201680 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18230822" @default.
- W2110201680 hasPublicationYear "2008" @default.
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