FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2110203435> ?p ?o ?g. }

• W2110203435 endingPage "751" @default.
• W2110203435 startingPage "741" @default.
• W2110203435 abstract "Abstract Müller cells, the primary macroglia of the retina, support various functions of retinal ganglion cells (RGCs). Here, we demonstrate a nucleotide‐mediated communication between these two types of cells, by which Müller cells control neurite outgrowth of RGCs by activation of P2 receptors such as P2Y 6 . Cultured mouse RGCs had significantly enhanced neurite outgrowth when cultured with either cultured mouse Müller cells or conditioned medium derived from Müller cells, and this was completely inhibited by the nucleotide‐degrading enzyme, apyrase. This increase in outgrowth was mimicked by exogenously applied nucleotides such as ATP, uridine triphosphate, and uridine diphosphate. Pharmacological and genetic analysis revealed that P2Y 6 receptor in RGCs was responsible for the increased neurite outgrowth. P2Y 6 receptor was expressed in the ganglion cell layer of the retina and in RGC primary cultures. High performance liquid chromatography has revealed that Müller cells constitutively release uridine triphosphate, which is immediately metabolized into uridine diphosphate, an endogenous agonist for P2Y 6 receptor. In the in vitro ocular hypertension model (i.e., glaucoma model), neurite outgrowth in RGCs was significantly reduced, which was associated with a decrease in P2Y 6 receptors. Taken together, Müller cells control neurite outgrowth of RGCs by activating P2 receptors such as P2Y 6 receptor, and the receptor expression level might be down‐regulated in glaucoma. image Müller cells support various functions of retina including those of retinal ganglion cells (RGCs). Here, we report an importance of nucleotide‐mediated communication between these two types of cells. Müller cells were found to release uridine diphosphate (UTD), uridine triphosphate (UTP), and activate P2Y6 receptors in RGCs, which was essential for neurite outgrowth of RGCs. In addition, P2Y 6 receptors in RGCs were reduced in a glaucoma model in vitro , suggesting an involvement of their dysfunction in the pathogenesis of glaucoma." @default.
• W2110203435 created "2016-06-24" @default.
• W2110203435 creator A5016507316 @default.
• W2110203435 creator A5026360034 @default.
• W2110203435 creator A5031977098 @default.
• W2110203435 creator A5052217673 @default.
• W2110203435 creator A5063168997 @default.
• W2110203435 creator A5088339831 @default.
• W2110203435 date "2015-12-17" @default.
• W2110203435 modified "2023-10-17" @default.
• W2110203435 title "Müller cell-mediated neurite outgrowth of the retinal ganglion cells via P2Y₆ receptor signals" @default.
• W2110203435 cites W1481168124 @default.
• W2110203435 cites W1488048016 @default.
• W2110203435 cites W1563498244 @default.
• W2110203435 cites W1973659906 @default.
• W2110203435 cites W1979851953 @default.
• W2110203435 cites W1990077068 @default.
• W2110203435 cites W1993224587 @default.
• W2110203435 cites W1996136926 @default.
• W2110203435 cites W1999928068 @default.
• W2110203435 cites W2004977662 @default.
• W2110203435 cites W2009486345 @default.
• W2110203435 cites W2011221727 @default.
• W2110203435 cites W2021814062 @default.
• W2110203435 cites W2025339136 @default.
• W2110203435 cites W2033152479 @default.
• W2110203435 cites W2044858838 @default.
• W2110203435 cites W2050233682 @default.
• W2110203435 cites W2053355036 @default.
• W2110203435 cites W2058050891 @default.
• W2110203435 cites W2058483899 @default.
• W2110203435 cites W2078810364 @default.
• W2110203435 cites W2080853291 @default.
• W2110203435 cites W2083886434 @default.
• W2110203435 cites W2084771203 @default.
• W2110203435 cites W2087371812 @default.
• W2110203435 cites W2092742762 @default.
• W2110203435 cites W2101679513 @default.
• W2110203435 cites W2128269805 @default.
• W2110203435 cites W2138974681 @default.
• W2110203435 cites W2139190743 @default.
• W2110203435 cites W2146645941 @default.
• W2110203435 cites W2149296483 @default.
• W2110203435 cites W2162590238 @default.
• W2110203435 cites W2166911878 @default.
• W2110203435 cites W2167860770 @default.
• W2110203435 cites W2171678969 @default.
• W2110203435 doi "https://doi.org/10.1111/jnc.13427" @default.
• W2110203435 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26560804" @default.
• W2110203435 hasPublicationYear "2015" @default.
• W2110203435 type Work @default.
• W2110203435 sameAs 2110203435 @default.
• W2110203435 citedByCount "16" @default.
• W2110203435 countsByYear W21102034352016 @default.
• W2110203435 countsByYear W21102034352017 @default.
• W2110203435 countsByYear W21102034352018 @default.
• W2110203435 countsByYear W21102034352019 @default.
• W2110203435 countsByYear W21102034352021 @default.
• W2110203435 countsByYear W21102034352022 @default.
• W2110203435 countsByYear W21102034352023 @default.
• W2110203435 crossrefType "journal-article" @default.
• W2110203435 hasAuthorship W2110203435A5016507316 @default.
• W2110203435 hasAuthorship W2110203435A5026360034 @default.
• W2110203435 hasAuthorship W2110203435A5031977098 @default.
• W2110203435 hasAuthorship W2110203435A5052217673 @default.
• W2110203435 hasAuthorship W2110203435A5063168997 @default.
• W2110203435 hasAuthorship W2110203435A5088339831 @default.
• W2110203435 hasBestOaLocation W21102034351 @default.
• W2110203435 hasConcept C104317684 @default.
• W2110203435 hasConcept C113246987 @default.
• W2110203435 hasConcept C153911025 @default.
• W2110203435 hasConcept C160225129 @default.
• W2110203435 hasConcept C169760540 @default.
• W2110203435 hasConcept C170493617 @default.
• W2110203435 hasConcept C181199279 @default.
• W2110203435 hasConcept C202751555 @default.
• W2110203435 hasConcept C2777093970 @default.
• W2110203435 hasConcept C2777624874 @default.
• W2110203435 hasConcept C2778152042 @default.
• W2110203435 hasConcept C2778564976 @default.
• W2110203435 hasConcept C2778938600 @default.
• W2110203435 hasConcept C512185932 @default.
• W2110203435 hasConcept C55493867 @default.
• W2110203435 hasConcept C86803240 @default.
• W2110203435 hasConcept C95444343 @default.
• W2110203435 hasConceptScore W2110203435C104317684 @default.
• W2110203435 hasConceptScore W2110203435C113246987 @default.
• W2110203435 hasConceptScore W2110203435C153911025 @default.
• W2110203435 hasConceptScore W2110203435C160225129 @default.
• W2110203435 hasConceptScore W2110203435C169760540 @default.
• W2110203435 hasConceptScore W2110203435C170493617 @default.
• W2110203435 hasConceptScore W2110203435C181199279 @default.
• W2110203435 hasConceptScore W2110203435C202751555 @default.
• W2110203435 hasConceptScore W2110203435C2777093970 @default.
• W2110203435 hasConceptScore W2110203435C2777624874 @default.
• W2110203435 hasConceptScore W2110203435C2778152042 @default.
• W2110203435 hasConceptScore W2110203435C2778564976 @default.
• W2110203435 hasConceptScore W2110203435C2778938600 @default.

• next