FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2110203824> ?p ?o ?g. }

• W2110203824 endingPage "3471" @default.
• W2110203824 startingPage "3462" @default.
• W2110203824 abstract "Abstract Inflammatory cytokines modulate immune responses in the tumor microenvironment during progression/metastasis. In this study, we have assessed the role of IL-1 and IL-17 in the control of antitumor immunity versus progression in a model of experimental lung metastasis, using 3LL and B16 epithelial tumor cells. The absence of IL-1 signaling or its excess in the lung microenvironment (in IL-1β and IL-1R antagonist knockout [KO] mice, respectively) resulted in a poor prognosis and reduced T cell activity, compared with WT mice. In IL-1β KO mice, enhanced T regulatory cell development/function, due to a favorable in situ cytokine network and impairment in APC maturation, resulted in suppressed antitumor immunity, whereas in IL-1R antagonist KO mice, enhanced accumulation and activity of myeloid-derived suppressor cells were found. Reduced tumor progression along with improved T cell function was found in IL-17 KO mice, compared with WT mice. In the microenvironment of lung tumors, IL-1 induces IL-17 through recruitment of γ/δ T cells and their activation for IL-17 production, with no involvement of Th17 cells. These interactions were specific to the microenvironment of lung tumors, as in intrafootpad tumors in IL-1/IL-17 KO mice, different patterns of invasiveness were observed and no IL-17 could be locally detected. The results highlight the critical and unique role of IL-1, and cytokines induced by it such as IL-17, in determining the balance between inflammation and antitumor immunity in specific tumor microenvironments. Also, we suggest that intervention in IL-1/IL-17 production could be therapeutically used to tilt this balance toward enhanced antitumor immunity." @default.
• W2110203824 created "2016-06-24" @default.
• W2110203824 creator A5025979230 @default.
• W2110203824 creator A5028992290 @default.
• W2110203824 creator A5032002909 @default.
• W2110203824 creator A5054584515 @default.
• W2110203824 creator A5058696220 @default.
• W2110203824 creator A5079119964 @default.
• W2110203824 creator A5082329994 @default.
• W2110203824 date "2011-03-15" @default.
• W2110203824 modified "2023-10-01" @default.
• W2110203824 title "Microenvironment-Derived IL-1 and IL-17 Interact in the Control of Lung Metastasis" @default.
• W2110203824 cites W1494453913 @default.
• W2110203824 cites W1502240334 @default.
• W2110203824 cites W1531548232 @default.
• W2110203824 cites W1537718629 @default.
• W2110203824 cites W1572174716 @default.
• W2110203824 cites W1984778685 @default.
• W2110203824 cites W1990681926 @default.
• W2110203824 cites W1993026721 @default.
• W2110203824 cites W1993187510 @default.
• W2110203824 cites W1999406693 @default.
• W2110203824 cites W2002409863 @default.
• W2110203824 cites W2004150448 @default.
• W2110203824 cites W2005623930 @default.
• W2110203824 cites W2006252261 @default.
• W2110203824 cites W2017316655 @default.
• W2110203824 cites W2021857124 @default.
• W2110203824 cites W2024490058 @default.
• W2110203824 cites W2029437196 @default.
• W2110203824 cites W2033345475 @default.
• W2110203824 cites W2043812762 @default.
• W2110203824 cites W2049094526 @default.
• W2110203824 cites W2050516456 @default.
• W2110203824 cites W2053829861 @default.
• W2110203824 cites W2056666823 @default.
• W2110203824 cites W2064282763 @default.
• W2110203824 cites W2065154189 @default.
• W2110203824 cites W2084545547 @default.
• W2110203824 cites W2092337193 @default.
• W2110203824 cites W2095167461 @default.
• W2110203824 cites W2100820895 @default.
• W2110203824 cites W2105724560 @default.
• W2110203824 cites W2106471879 @default.
• W2110203824 cites W2109666345 @default.
• W2110203824 cites W2111045447 @default.
• W2110203824 cites W2112866067 @default.
• W2110203824 cites W2117047064 @default.
• W2110203824 cites W2118278569 @default.
• W2110203824 cites W2123105952 @default.
• W2110203824 cites W2126882378 @default.
• W2110203824 cites W2126889178 @default.
• W2110203824 cites W2131186715 @default.
• W2110203824 cites W2136757803 @default.
• W2110203824 cites W2142300779 @default.
• W2110203824 cites W2155510706 @default.
• W2110203824 cites W2156451877 @default.
• W2110203824 cites W2157269800 @default.
• W2110203824 cites W2158300165 @default.
• W2110203824 cites W2165064029 @default.
• W2110203824 cites W2165275387 @default.
• W2110203824 cites W2171481006 @default.
• W2110203824 doi "https://doi.org/10.4049/jimmunol.1002901" @default.
• W2110203824 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21300825" @default.
• W2110203824 hasPublicationYear "2011" @default.
• W2110203824 type Work @default.
• W2110203824 sameAs 2110203824 @default.
• W2110203824 citedByCount "100" @default.
• W2110203824 countsByYear W21102038242012 @default.
• W2110203824 countsByYear W21102038242013 @default.
• W2110203824 countsByYear W21102038242014 @default.
• W2110203824 countsByYear W21102038242015 @default.
• W2110203824 countsByYear W21102038242016 @default.
• W2110203824 countsByYear W21102038242017 @default.
• W2110203824 countsByYear W21102038242018 @default.
• W2110203824 countsByYear W21102038242019 @default.
• W2110203824 countsByYear W21102038242020 @default.
• W2110203824 countsByYear W21102038242021 @default.
• W2110203824 countsByYear W21102038242022 @default.
• W2110203824 countsByYear W21102038242023 @default.
• W2110203824 crossrefType "journal-article" @default.
• W2110203824 hasAuthorship W2110203824A5025979230 @default.
• W2110203824 hasAuthorship W2110203824A5028992290 @default.
• W2110203824 hasAuthorship W2110203824A5032002909 @default.
• W2110203824 hasAuthorship W2110203824A5054584515 @default.
• W2110203824 hasAuthorship W2110203824A5058696220 @default.
• W2110203824 hasAuthorship W2110203824A5079119964 @default.
• W2110203824 hasAuthorship W2110203824A5082329994 @default.
• W2110203824 hasBestOaLocation W21102038241 @default.
• W2110203824 hasConcept C121608353 @default.
• W2110203824 hasConcept C126322002 @default.
• W2110203824 hasConcept C203014093 @default.
• W2110203824 hasConcept C2776090121 @default.
• W2110203824 hasConcept C2776107976 @default.
• W2110203824 hasConcept C2776914184 @default.
• W2110203824 hasConcept C2778690821 @default.
• W2110203824 hasConcept C2779013556 @default.
• W2110203824 hasConcept C2779256057 @default.

• next