Matches in SemOpenAlex for { <https://semopenalex.org/work/W2110223801> ?p ?o ?g. }
- W2110223801 endingPage "511" @default.
- W2110223801 startingPage "499" @default.
- W2110223801 abstract "Synthetic oligodeoxynucleotides (ODNs) containing unmethylated CpG motifs trigger cells that express Toll-like receptor 9 (including human plasmacytoid dendritic cells and B cells) to mount an innate immune response characterized by the production of Th1 and proinflammatory cytokines. When used as vaccine adjuvants, CpG ODNs improve the function of professional antigen-presenting cells and boost the generation of humoral and cellular vaccine-specific immune responses. These effects are optimized by maintaining ODNs and vaccine in close proximity. The adjuvant properties of CpG ODNs are observed when administered either systemically or mucosally, and persist in immunocompromised hosts. Preclinical studies indicate that CpG ODNs improve the activity of vaccines targeting infectious diseases and cancer. Clinical trials demonstrate that CpG ODNs have a good safety profile and increase the immunogenicity of coadministered vaccines." @default.
- W2110223801 created "2016-06-24" @default.
- W2110223801 creator A5024898063 @default.
- W2110223801 creator A5030604997 @default.
- W2110223801 creator A5043470455 @default.
- W2110223801 creator A5055670410 @default.
- W2110223801 creator A5083907920 @default.
- W2110223801 date "2011-04-01" @default.
- W2110223801 modified "2023-09-30" @default.
- W2110223801 title "CpG DNA as a vaccine adjuvant" @default.
- W2110223801 cites W135934099 @default.
- W2110223801 cites W1478898356 @default.
- W2110223801 cites W1485179699 @default.
- W2110223801 cites W1505469822 @default.
- W2110223801 cites W1514540900 @default.
- W2110223801 cites W1524792851 @default.
- W2110223801 cites W1536488163 @default.
- W2110223801 cites W1537631996 @default.
- W2110223801 cites W1538844879 @default.
- W2110223801 cites W1544722565 @default.
- W2110223801 cites W1547938117 @default.
- W2110223801 cites W1549003425 @default.
- W2110223801 cites W1577343949 @default.
- W2110223801 cites W1588809288 @default.
- W2110223801 cites W1596740642 @default.
- W2110223801 cites W1603446342 @default.
- W2110223801 cites W1606632249 @default.
- W2110223801 cites W1611703640 @default.
- W2110223801 cites W1636901091 @default.
- W2110223801 cites W1858598335 @default.
- W2110223801 cites W1903411571 @default.
- W2110223801 cites W1917892434 @default.
- W2110223801 cites W1956007715 @default.
- W2110223801 cites W1964163749 @default.
- W2110223801 cites W1964196894 @default.
- W2110223801 cites W1965565095 @default.
- W2110223801 cites W1967742157 @default.
- W2110223801 cites W1972171725 @default.
- W2110223801 cites W1973488341 @default.
- W2110223801 cites W1974079625 @default.
- W2110223801 cites W1975785277 @default.
- W2110223801 cites W1978772005 @default.
- W2110223801 cites W1979956993 @default.
- W2110223801 cites W1984618863 @default.
- W2110223801 cites W1986097339 @default.
- W2110223801 cites W1986315531 @default.
- W2110223801 cites W1988711597 @default.
- W2110223801 cites W1990834356 @default.
- W2110223801 cites W1993000082 @default.
- W2110223801 cites W1993894494 @default.
- W2110223801 cites W1995744610 @default.
- W2110223801 cites W1995991884 @default.
- W2110223801 cites W1999070120 @default.
- W2110223801 cites W2002360900 @default.
- W2110223801 cites W2002789828 @default.
- W2110223801 cites W2003841064 @default.
- W2110223801 cites W2004107411 @default.
- W2110223801 cites W2006617601 @default.
- W2110223801 cites W2008641198 @default.
- W2110223801 cites W2009997208 @default.
- W2110223801 cites W2010222913 @default.
- W2110223801 cites W2011868039 @default.
- W2110223801 cites W2016629087 @default.
- W2110223801 cites W2025345914 @default.
- W2110223801 cites W2030534966 @default.
- W2110223801 cites W2030562643 @default.
- W2110223801 cites W2032783993 @default.
- W2110223801 cites W2033441782 @default.
- W2110223801 cites W2034259068 @default.
- W2110223801 cites W2035907681 @default.
- W2110223801 cites W2036405516 @default.
- W2110223801 cites W2037233457 @default.
- W2110223801 cites W2041340424 @default.
- W2110223801 cites W2042368250 @default.
- W2110223801 cites W2045971655 @default.
- W2110223801 cites W2047366876 @default.
- W2110223801 cites W2047417656 @default.
- W2110223801 cites W2048069351 @default.
- W2110223801 cites W2050181420 @default.
- W2110223801 cites W2052521175 @default.
- W2110223801 cites W2056200812 @default.
- W2110223801 cites W2057055727 @default.
- W2110223801 cites W2058374284 @default.
- W2110223801 cites W2058649253 @default.
- W2110223801 cites W2059427031 @default.
- W2110223801 cites W2061812402 @default.
- W2110223801 cites W2062350041 @default.
- W2110223801 cites W2063587348 @default.
- W2110223801 cites W2064416244 @default.
- W2110223801 cites W2065385462 @default.
- W2110223801 cites W2067748709 @default.
- W2110223801 cites W2068264979 @default.
- W2110223801 cites W2068441823 @default.
- W2110223801 cites W2069981713 @default.
- W2110223801 cites W2073990520 @default.
- W2110223801 cites W2074778496 @default.
- W2110223801 cites W2075789186 @default.
- W2110223801 cites W2078886053 @default.