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- W2110230025 abstract "Src family kinases are central regulators of a large number of signaling pathways. To adapt to the idiosyncrasies of different cell types, these kinases may need a fine-tuning of their intrinsic molecular control mechanisms. Here, we describe on a molecular level how the Fyn kinase uses alternative splicing to adapt to different cellular environments. Using structural analysis, site-directed mutagenesis, and functional analysis, we show how the inclusion of either exon 7A or 7B affects the autoinhibition of Fyn and how this changes the SH3-dependent interaction and tyrosine phosphorylation of Sam68, with functional consequences for the Sam68-regulated survival of epithelial cells. Our results illustrate a novel mechanism of evolution that may contribute to the complexity of Src kinase regulation." @default.
- W2110230025 created "2016-06-24" @default.
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- W2110230025 date "2009-12-01" @default.
- W2110230025 modified "2023-09-30" @default.
- W2110230025 title "Alternative Splicing Modulates Autoinhibition and SH3 Accessibility in the Src Kinase Fyn" @default.
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- W2110230025 doi "https://doi.org/10.1128/mcb.00398-09" @default.
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