FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2110236416> ?p ?o ?g. }

• W2110236416 endingPage "387" @default.
• W2110236416 startingPage "378" @default.
• W2110236416 abstract "Chronic hepatitis B virus (HBV) infection is an independent risk factor for the development of hepatocellular carcinoma (HCC). The HBV HBx gene is frequently identified as an integrant in the chromosomal DNA of patients with HCC. HBx encodes the X protein (HBx), a putative viral oncoprotein that affects transcriptional regulation of several cellular genes. Therefore, HBx may be an ideal target to impede the progression of HBV infection-related HCC. In this study, integrated HBx was transcriptionally downregulated using an artificial transcription factor (ATF). Two three-fingered Cys2-His2 zinc finger (ZF) motifs that specifically recognized two 9-bp DNA sequences regulating HBx expression were identified from a phage-display library. The ZF domains were linked into a six-fingered protein that specified an 18-bp DNA target in the Enhancer I region upstream of HBx. This DNA-binding domain was fused with a Krüppel-associated box (KRAB) transcriptional repression domain to produce an ATF designed to downregulate HBx integrated into the Hep3B HCC cell line. The ATF significantly repressed HBx in a luciferase reporter assay. Stably expressing the ATF in Hep3B cells resulted in significant growth arrest, whereas stably expressing the ATF in an HCC cell line lacking integrated HBx (HepG2) had virtually no effect. The targeted downregulation of integrated HBx is a promising novel approach to inhibiting the progression of HBV infection-related HCC." @default.
• W2110236416 created "2016-06-24" @default.
• W2110236416 creator A5003217623 @default.
• W2110236416 creator A5007238584 @default.
• W2110236416 creator A5007732950 @default.
• W2110236416 creator A5016881449 @default.
• W2110236416 creator A5017541508 @default.
• W2110236416 creator A5024721469 @default.
• W2110236416 creator A5027596703 @default.
• W2110236416 creator A5031582995 @default.
• W2110236416 creator A5034054749 @default.
• W2110236416 creator A5034995105 @default.
• W2110236416 creator A5035509854 @default.
• W2110236416 creator A5036879846 @default.
• W2110236416 creator A5040078686 @default.
• W2110236416 creator A5044332273 @default.
• W2110236416 creator A5047901883 @default.
• W2110236416 creator A5050236002 @default.
• W2110236416 creator A5051323527 @default.
• W2110236416 creator A5051967089 @default.
• W2110236416 creator A5060815622 @default.
• W2110236416 creator A5061952948 @default.
• W2110236416 creator A5070505636 @default.
• W2110236416 creator A5071672663 @default.
• W2110236416 creator A5072922736 @default.
• W2110236416 creator A5083507974 @default.
• W2110236416 creator A5090911302 @default.
• W2110236416 creator A5091586835 @default.
• W2110236416 date "2013-04-01" @default.
• W2110236416 modified "2023-10-05" @default.
• W2110236416 title "Creation of a Six-fingered Artificial Transcription Factor That Represses the Hepatitis B Virus HBx Gene Integrated into a Human Hepatocellular Carcinoma Cell Line" @default.
• W2110236416 cites W1582870526 @default.
• W2110236416 cites W1594881865 @default.
• W2110236416 cites W1690185597 @default.
• W2110236416 cites W1964190660 @default.
• W2110236416 cites W1969418855 @default.
• W2110236416 cites W1980294836 @default.
• W2110236416 cites W1986150533 @default.
• W2110236416 cites W1989312510 @default.
• W2110236416 cites W1990198702 @default.
• W2110236416 cites W1994060716 @default.
• W2110236416 cites W1996926729 @default.
• W2110236416 cites W2009415813 @default.
• W2110236416 cites W2011257176 @default.
• W2110236416 cites W2032015331 @default.
• W2110236416 cites W2039887107 @default.
• W2110236416 cites W2043925666 @default.
• W2110236416 cites W2044741494 @default.
• W2110236416 cites W2057211093 @default.
• W2110236416 cites W2086865943 @default.
• W2110236416 cites W2100335842 @default.
• W2110236416 cites W2102423567 @default.
• W2110236416 cites W2103013819 @default.
• W2110236416 cites W2106787323 @default.
• W2110236416 cites W2127993547 @default.
• W2110236416 cites W2132291850 @default.
• W2110236416 cites W2137052325 @default.
• W2110236416 cites W2146527422 @default.
• W2110236416 cites W2160365835 @default.
• W2110236416 cites W4211067702 @default.
• W2110236416 doi "https://doi.org/10.1177/1087057112463066" @default.
• W2110236416 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23042077" @default.
• W2110236416 hasPublicationYear "2013" @default.
• W2110236416 type Work @default.
• W2110236416 sameAs 2110236416 @default.
• W2110236416 citedByCount "14" @default.
• W2110236416 countsByYear W21102364162015 @default.
• W2110236416 countsByYear W21102364162016 @default.
• W2110236416 countsByYear W21102364162017 @default.
• W2110236416 countsByYear W21102364162018 @default.
• W2110236416 countsByYear W21102364162019 @default.
• W2110236416 countsByYear W21102364162021 @default.
• W2110236416 countsByYear W21102364162022 @default.
• W2110236416 countsByYear W21102364162023 @default.
• W2110236416 crossrefType "journal-article" @default.
• W2110236416 hasAuthorship W2110236416A5003217623 @default.
• W2110236416 hasAuthorship W2110236416A5007238584 @default.
• W2110236416 hasAuthorship W2110236416A5007732950 @default.
• W2110236416 hasAuthorship W2110236416A5016881449 @default.
• W2110236416 hasAuthorship W2110236416A5017541508 @default.
• W2110236416 hasAuthorship W2110236416A5024721469 @default.
• W2110236416 hasAuthorship W2110236416A5027596703 @default.
• W2110236416 hasAuthorship W2110236416A5031582995 @default.
• W2110236416 hasAuthorship W2110236416A5034054749 @default.
• W2110236416 hasAuthorship W2110236416A5034995105 @default.
• W2110236416 hasAuthorship W2110236416A5035509854 @default.
• W2110236416 hasAuthorship W2110236416A5036879846 @default.
• W2110236416 hasAuthorship W2110236416A5040078686 @default.
• W2110236416 hasAuthorship W2110236416A5044332273 @default.
• W2110236416 hasAuthorship W2110236416A5047901883 @default.
• W2110236416 hasAuthorship W2110236416A5050236002 @default.
• W2110236416 hasAuthorship W2110236416A5051323527 @default.
• W2110236416 hasAuthorship W2110236416A5051967089 @default.
• W2110236416 hasAuthorship W2110236416A5060815622 @default.
• W2110236416 hasAuthorship W2110236416A5061952948 @default.
• W2110236416 hasAuthorship W2110236416A5070505636 @default.
• W2110236416 hasAuthorship W2110236416A5071672663 @default.
• W2110236416 hasAuthorship W2110236416A5072922736 @default.

• next