FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2110249350> ?p ?o ?g. }

• W2110249350 endingPage "135" @default.
• W2110249350 startingPage "129" @default.
• W2110249350 abstract "Effects of intrauterine hypoxia-ischemia (HI) on receptor-stimulated phosphoinositide (PPI) hydrolysis were studied in rat cerebellar granule cell cultures prepared from an in utero HI model. On gestation day 17, HI conditions were achieved by complete clamping of the uterine vasculature for 30 min followed by removal of the clamps to permit reperfusion. Sham operation (SH, surgery without vasculature ligation) was performed as the control. Intrauterine HI did not affect the basal level of PPI hydrolysis (in the absence of stimulants) in cells prepared from either the SH or the HI group. PPI hydrolysis stimulated by quisqualate (QA) or trans-(1S,3R)-1-amino-1,3-cyclo-pentanedicarboxylic acid (trans-ACPD) was significantly reduced in cells prepared from the HI group, whereas intrauterine HI did not affect the PPI hydrolysis induced by ionotropic glutamate receptor agonists or by norepinephrine or serotonin. At a dose range of 100-300 microM, QA-stimulated PPI hydrolysis in cells prepared from the SH group increased by 3-to 4.5-fold, while this increase was only 2- to 2.5-fold in cells prepared from the HI group. Presence of L-NG-monomethyl-arginine (L-NMMA), a nitric oxide (NO) synthase inhibitor, did not increase QA-stimulated PPI hydrolysis in cells prepared from either the SH or the HI group, indicating that stimulation of NO formation is unlikely involved in the suppressive effects of intrauterine HI on QA-induced PPI hydrolysis. The QA-stimulated PPI hydrolysis in cells prepared from the HI group, but not from the SH group, was further inhibited by L-(+)-2-amino-3-phosphono-propionic acid (L-AP3). The overall results suggest that intrauterine HI has long-lasting suppressive effects on metabotropic glutamate receptor agonist-stimulated PPI hydrolysis and these effects might be associated with alterations in expression of metabotropic glutamate receptor subtypes." @default.
• W2110249350 created "2016-06-24" @default.
• W2110249350 creator A5022413671 @default.
• W2110249350 creator A5048874632 @default.
• W2110249350 date "1996-05-01" @default.
• W2110249350 modified "2023-09-25" @default.
• W2110249350 title "Intrauterine hypoxia-ischemia reduces phosphoinositide hydrolysis stimulated by metabotropic glutamate receptor agonists in cultured rat cerebellar granule cells" @default.
• W2110249350 cites W1503789839 @default.
• W2110249350 cites W1557790606 @default.
• W2110249350 cites W1577688470 @default.
• W2110249350 cites W1636078186 @default.
• W2110249350 cites W1889236699 @default.
• W2110249350 cites W1968842968 @default.
• W2110249350 cites W1991459473 @default.
• W2110249350 cites W1998530498 @default.
• W2110249350 cites W2005168281 @default.
• W2110249350 cites W2006373502 @default.
• W2110249350 cites W2013496429 @default.
• W2110249350 cites W2014746504 @default.
• W2110249350 cites W2023811880 @default.
• W2110249350 cites W2030353964 @default.
• W2110249350 cites W2041644100 @default.
• W2110249350 cites W2042550512 @default.
• W2110249350 cites W2054192281 @default.
• W2110249350 cites W2059453881 @default.
• W2110249350 cites W2059799186 @default.
• W2110249350 cites W2060970517 @default.
• W2110249350 cites W2066439059 @default.
• W2110249350 cites W2067080574 @default.
• W2110249350 cites W2078935283 @default.
• W2110249350 cites W2080120821 @default.
• W2110249350 cites W2088374599 @default.
• W2110249350 cites W2092588893 @default.
• W2110249350 cites W2095393025 @default.
• W2110249350 cites W2128635872 @default.
• W2110249350 cites W2136189765 @default.
• W2110249350 cites W2136227999 @default.
• W2110249350 cites W2156249921 @default.
• W2110249350 cites W2161584310 @default.
• W2110249350 cites W2165504047 @default.
• W2110249350 cites W2174668858 @default.
• W2110249350 cites W2462774249 @default.
• W2110249350 cites W98095360 @default.
• W2110249350 cites W2040456704 @default.
• W2110249350 doi "https://doi.org/10.1016/0165-3806(96)00022-3" @default.
• W2110249350 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8804699" @default.
• W2110249350 hasPublicationYear "1996" @default.
• W2110249350 type Work @default.
• W2110249350 sameAs 2110249350 @default.
• W2110249350 citedByCount "4" @default.
• W2110249350 crossrefType "journal-article" @default.
• W2110249350 hasAuthorship W2110249350A5022413671 @default.
• W2110249350 hasAuthorship W2110249350A5048874632 @default.
• W2110249350 hasConcept C126322002 @default.
• W2110249350 hasConcept C134018914 @default.
• W2110249350 hasConcept C170493617 @default.
• W2110249350 hasConcept C26702167 @default.
• W2110249350 hasConcept C2778938600 @default.
• W2110249350 hasConcept C49051014 @default.
• W2110249350 hasConcept C55493867 @default.
• W2110249350 hasConcept C61174792 @default.
• W2110249350 hasConcept C67018056 @default.
• W2110249350 hasConcept C71924100 @default.
• W2110249350 hasConcept C86803240 @default.
• W2110249350 hasConceptScore W2110249350C126322002 @default.
• W2110249350 hasConceptScore W2110249350C134018914 @default.
• W2110249350 hasConceptScore W2110249350C170493617 @default.
• W2110249350 hasConceptScore W2110249350C26702167 @default.
• W2110249350 hasConceptScore W2110249350C2778938600 @default.
• W2110249350 hasConceptScore W2110249350C49051014 @default.
• W2110249350 hasConceptScore W2110249350C55493867 @default.
• W2110249350 hasConceptScore W2110249350C61174792 @default.
• W2110249350 hasConceptScore W2110249350C67018056 @default.
• W2110249350 hasConceptScore W2110249350C71924100 @default.
• W2110249350 hasConceptScore W2110249350C86803240 @default.
• W2110249350 hasIssue "1-2" @default.
• W2110249350 hasLocation W21102493501 @default.
• W2110249350 hasLocation W21102493502 @default.
• W2110249350 hasOpenAccess W2110249350 @default.
• W2110249350 hasPrimaryLocation W21102493501 @default.
• W2110249350 hasRelatedWork W2001165441 @default.
• W2110249350 hasRelatedWork W2009311043 @default.
• W2110249350 hasRelatedWork W2023472991 @default.
• W2110249350 hasRelatedWork W2028497563 @default.
• W2110249350 hasRelatedWork W2041098374 @default.
• W2110249350 hasRelatedWork W2053013201 @default.
• W2110249350 hasRelatedWork W2055476559 @default.
• W2110249350 hasRelatedWork W2062464911 @default.
• W2110249350 hasRelatedWork W2107519202 @default.
• W2110249350 hasRelatedWork W4229998764 @default.
• W2110249350 hasVolume "93" @default.
• W2110249350 isParatext "false" @default.
• W2110249350 isRetracted "false" @default.
• W2110249350 magId "2110249350" @default.
• W2110249350 workType "article" @default.