Matches in SemOpenAlex for { <https://semopenalex.org/work/W2110253587> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2110253587 endingPage "642" @default.
- W2110253587 startingPage "637" @default.
- W2110253587 abstract "Background : A combination of omeprazole, clarithromycin and either metronidazole or tinidazole is commonly used for Helicobacter pylori eradication. Metronidazole is considerably cheaper than tinidazole but the two have not previously been compared in a randomized trial. Methods : One hundred and twenty dyspeptic H. pylori ‐positive patients with endoscopically defined peptic ulcer [DU ( n = 65), GU ( n = 12)] or non‐ulcer dyspepsia (NUD, n = 43) were randomized to receive a 1‐week course of twice daily omeprazole 20 mg, clarithromycin 250 mg and either metronidazole 400 mg (OCM) or tinidazole 500 mg (OCT) in a double‐blind fashion. Eradication of H. pylori , safety and side‐effects of treatment, dyspeptic symptom score and consumption of antisecretory drugs were assessed at 6 weeks and 1 year after treatment. Results : H. pylori eradication was successfully achieved in 57/60 (95%, ITT analysis) of patients receiving OCT and 58/60 (97%, ITT analysis) receiving OCM. Both regimens had similar side‐effect profiles, which accounted for only one patient withdrawal. All patients remained uninfected (as assessed by 14 C‐urea breath test) at 1‐year follow‐up, but major symptom improvements and decreased antisecretory drug use were only seen in patients with DU ( P < 0.0001). Conclusions : Treatment with OCM is as effective as the more expensive OCT at eradicating H. pylori. H. pylori eradication results in long‐term relief of dyspeptic symptoms and reduced antisecretory consumption only in patients with DU, and not in those with NUD." @default.
- W2110253587 created "2016-06-24" @default.
- W2110253587 creator A5028232421 @default.
- W2110253587 creator A5052149673 @default.
- W2110253587 creator A5075931666 @default.
- W2110253587 creator A5084185483 @default.
- W2110253587 date "1999-05-01" @default.
- W2110253587 modified "2023-10-18" @default.
- W2110253587 title "Randomized controlled comparison of nitroimidazoles for the eradication of <i>Helicobacter pylori</i> and relief of ulcer‐associated and non‐ulcer dyspepsia" @default.
- W2110253587 cites W172383029 @default.
- W2110253587 cites W1958366167 @default.
- W2110253587 cites W1964710477 @default.
- W2110253587 cites W1989576230 @default.
- W2110253587 cites W1989739317 @default.
- W2110253587 cites W1995018598 @default.
- W2110253587 cites W2002984229 @default.
- W2110253587 cites W2005670414 @default.
- W2110253587 cites W2007380445 @default.
- W2110253587 cites W2011589019 @default.
- W2110253587 cites W2047542337 @default.
- W2110253587 cites W2068007231 @default.
- W2110253587 cites W2072396675 @default.
- W2110253587 cites W2077747080 @default.
- W2110253587 cites W2098709209 @default.
- W2110253587 cites W2123848597 @default.
- W2110253587 cites W2427501075 @default.
- W2110253587 cites W2054148637 @default.
- W2110253587 doi "https://doi.org/10.1046/j.1365-2036.1999.00513.x" @default.
- W2110253587 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10233187" @default.
- W2110253587 hasPublicationYear "1999" @default.
- W2110253587 type Work @default.
- W2110253587 sameAs 2110253587 @default.
- W2110253587 citedByCount "8" @default.
- W2110253587 crossrefType "journal-article" @default.
- W2110253587 hasAuthorship W2110253587A5028232421 @default.
- W2110253587 hasAuthorship W2110253587A5052149673 @default.
- W2110253587 hasAuthorship W2110253587A5075931666 @default.
- W2110253587 hasAuthorship W2110253587A5084185483 @default.
- W2110253587 hasConcept C126322002 @default.
- W2110253587 hasConcept C168563851 @default.
- W2110253587 hasConcept C2775981797 @default.
- W2110253587 hasConcept C2776409635 @default.
- W2110253587 hasConcept C2776962512 @default.
- W2110253587 hasConcept C2777172195 @default.
- W2110253587 hasConcept C2777396551 @default.
- W2110253587 hasConcept C2777498785 @default.
- W2110253587 hasConcept C2778677798 @default.
- W2110253587 hasConcept C2779137044 @default.
- W2110253587 hasConcept C2780626017 @default.
- W2110253587 hasConcept C2908868296 @default.
- W2110253587 hasConcept C501593827 @default.
- W2110253587 hasConcept C71924100 @default.
- W2110253587 hasConcept C86803240 @default.
- W2110253587 hasConcept C89423630 @default.
- W2110253587 hasConcept C90924648 @default.
- W2110253587 hasConceptScore W2110253587C126322002 @default.
- W2110253587 hasConceptScore W2110253587C168563851 @default.
- W2110253587 hasConceptScore W2110253587C2775981797 @default.
- W2110253587 hasConceptScore W2110253587C2776409635 @default.
- W2110253587 hasConceptScore W2110253587C2776962512 @default.
- W2110253587 hasConceptScore W2110253587C2777172195 @default.
- W2110253587 hasConceptScore W2110253587C2777396551 @default.
- W2110253587 hasConceptScore W2110253587C2777498785 @default.
- W2110253587 hasConceptScore W2110253587C2778677798 @default.
- W2110253587 hasConceptScore W2110253587C2779137044 @default.
- W2110253587 hasConceptScore W2110253587C2780626017 @default.
- W2110253587 hasConceptScore W2110253587C2908868296 @default.
- W2110253587 hasConceptScore W2110253587C501593827 @default.
- W2110253587 hasConceptScore W2110253587C71924100 @default.
- W2110253587 hasConceptScore W2110253587C86803240 @default.
- W2110253587 hasConceptScore W2110253587C89423630 @default.
- W2110253587 hasConceptScore W2110253587C90924648 @default.
- W2110253587 hasIssue "5" @default.
- W2110253587 hasLocation W21102535871 @default.
- W2110253587 hasLocation W21102535872 @default.
- W2110253587 hasOpenAccess W2110253587 @default.
- W2110253587 hasPrimaryLocation W21102535871 @default.
- W2110253587 hasRelatedWork W169227193 @default.
- W2110253587 hasRelatedWork W2037514532 @default.
- W2110253587 hasRelatedWork W2056130369 @default.
- W2110253587 hasRelatedWork W2058774690 @default.
- W2110253587 hasRelatedWork W2350864918 @default.
- W2110253587 hasRelatedWork W2406657808 @default.
- W2110253587 hasRelatedWork W2411962044 @default.
- W2110253587 hasRelatedWork W2435251688 @default.
- W2110253587 hasRelatedWork W3205746115 @default.
- W2110253587 hasRelatedWork W3151993047 @default.
- W2110253587 hasVolume "13" @default.
- W2110253587 isParatext "false" @default.
- W2110253587 isRetracted "false" @default.
- W2110253587 magId "2110253587" @default.
- W2110253587 workType "article" @default.