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- W2110256914 abstract "Post-translational modification by the small ubiquitin-related modifier (SUMO) is important for a variety of cellular and developmental processes. However, the precise mechanism(s) that connects sumoylation to specific developmental signaling pathways remains relatively less clear. Here, we show that Smt3 knockdown in Drosophila wing discs causes phenotypes resembling JNK gain of function, including ectopic apoptosis and apoptosis-induced compensatory growth. Smt3 depletion leads to an increased expression of JNK target genes Mmp1 and puckered. We show that, although knockdown of the homeodomain-interacting protein kinase (Hipk) suppresses Smt3 depletion-induced activation of JNK, Hipk overexpression synergistically enhances this type of JNK activation. We further demonstrate that Hipk is sumolylated in vivo, and its nuclear localization is dependent on the sumoylation pathway. Our results thus establish a mechanistic connection between the sumoylation pathway and the JNK pathway through the action of Hipk. We propose that the sumoylation-controlled balance between cytoplasmic and nuclear Hipk plays a crucial role in regulating JNK signaling." @default.
- W2110256914 created "2016-06-24" @default.
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- W2110256914 date "2011-06-15" @default.
- W2110256914 modified "2023-09-29" @default.
- W2110256914 title "<i>Drosophila</i> Smt3 negatively regulates JNK signaling through sequestering Hipk in the nucleus" @default.
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- W2110256914 cites W1965856748 @default.
- W2110256914 cites W1970042886 @default.
- W2110256914 cites W1970061483 @default.
- W2110256914 cites W1970488978 @default.
- W2110256914 cites W1974714162 @default.
- W2110256914 cites W1976385326 @default.
- W2110256914 cites W1979874497 @default.
- W2110256914 cites W1985012020 @default.
- W2110256914 cites W1990248374 @default.
- W2110256914 cites W1991326375 @default.
- W2110256914 cites W1992486930 @default.
- W2110256914 cites W1994432533 @default.
- W2110256914 cites W1999057135 @default.
- W2110256914 cites W2013108773 @default.
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- W2110256914 cites W2023331434 @default.
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- W2110256914 cites W2031258074 @default.
- W2110256914 cites W2034596702 @default.
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- W2110256914 doi "https://doi.org/10.1242/dev.061770" @default.
- W2110256914 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21561986" @default.
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