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• W2110264098 abstract "Although both hepatocyte growth factor (HGF) and interleukin (IL)-6 play important roles in invasion of cancer cells, interaction between these two critical factors has not been well elucidated. In the present study we demonstrated a two-way interaction between HGF and IL-6 in in vitro invasion of a lung cancer cell line. A549 lung adenocarcinoma cells were stimulated with IL-6, and this treatment induced an upregulation of c-Met/HGF receptor mRNA expression in the cells. In addition, IL-6 enhanced the HGF-induced in vitro cell invasion. This effect was abolished by pretreatment of the cells with either anti-IL-6 neutralizing antibody or with anti-c-Met/HGF receptor blocking antibody. We also found that HGF upregulated the expression of IL-6 receptor mRNA in the same cell line, and that this upregulation enhanced the IL-6-induced cell invasion. Finally, costimulation with HGF and IL-6 showed an additive effect on invasion, and this effect was mediated by production of matrix metalloproteinase (MMP)-2 and MMP-9. These results suggest that HGF and IL-6 upregulate each other's receptors, and thus would cooperatively enhance tissue invasion. They also suggest an autocrine circuit among cytokines and growth factors in certain cancer cells which functions to accelerate their biologic activities such as metastatic property." @default.
• W2110264098 created "2016-06-24" @default.
• W2110264098 creator A5011867569 @default.
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• W2110264098 date "2002-08-01" @default.
• W2110264098 modified "2023-10-01" @default.
• W2110264098 title "A Two-way Interaction between Hepatocyte Growth Factor and Interleukin-6 in Tissue Invasion of Lung Cancer Cell Line" @default.
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• W2110264098 doi "https://doi.org/10.1165/ajrcmb.27.2.4804" @default.
• W2110264098 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12151314" @default.
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