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- W2110264893 abstract "Alzheimer's disease (AD) is the most common cause of dementia in people over 65 years, being considered one of the major public worldwide health problems. Patients with AD exhibit altered metabolic processes, which provokes neuronal death. The progressive loss of neurons in the brain, along with the formation of amyloid plaques and neurofibrillary tangles are pathological markers of the disease. The amyloid plaques are located in the intercellular spaces, consisting of large deposits of β-amyloid peptide (βA). The amyloid precursor protein (APP) is a key element in the amyloid cascade. The APP is sequentially cleaved by β- and γ-secretases to generateβA Formation of βA (amyloidogenic pathway) is prevented by α-secretases (non-amyloidogenic pathway), which have been identified as ADAM9, 10 and 17. A pioneer study with AD patients showed the expression of platelet ADAM10 is significantly reduced in AD patients platelets when compared to controls patients. The objective of this study was to correlate performance on the Mini-Mental State Examination (MMSE) and platelet levels of ADAM10 protein in AD patients, who is users of health services in the São Carlos-SP city. It was a case-control, cross-sectional and descriptive study, approved by The Ethics Committee on Human Research of the Federal University of São Carlos, No. 427/2009, which was conducted with 19 subjects distributed into two distinct groups, one by AD patients and another by healthy elderly. Extensive exclusion criteria were applied, and the application of instruments such as the Clinical Dementia Rating (CDR) and MMSE was used. In the second stage of the study, blood samples were collected from subjects measure the platelet ADAM10 expression levels. Several parameters were analyzed in both groups, among them gender, age and scholarity. The results revealed a decreased expression of ADAM10 in patients with AD compared to the control group (p<0,0001) and showed a correlation between the levels of ADAM10 and MMSE (p=0,0002). Combining the results of ADAM10 expression, cognitive tests and imaging studies, may become an important tool for early and accurate clinical diagnosis of AD." @default.
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- W2110264893 date "2014-07-01" @default.
- W2110264893 modified "2023-09-27" @default.
- W2110264893 title "P2-070: ADAM10 AS A CANDIDATE BIOMARKER FOR ALZHEIMER'S DISEASE" @default.
- W2110264893 doi "https://doi.org/10.1016/j.jalz.2014.05.744" @default.
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