FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2110270306> ?p ?o ?g. }

• W2110270306 endingPage "842" @default.
• W2110270306 startingPage "836" @default.
• W2110270306 abstract "Chronic infection of mice with the cestode Mesocestoides corti results in an antibody response restricted to immunoglobulins M (IgM) and G1 (IgG1). To determine which of the known lymphokines are involved in the restricted isotype response, we treated M. corti-infected mice with a panel of anticytokine monoclonal antibodies against interleukin-4 (IL-4), IL-5, IL-6, and gamma interferon. The effects of anti-IL-4 were of particular importance, since IL-4 is known to enhance IgG1 production and an IgG1 response predominates in infected animals. Interestingly, injection of anti-IL-4 alone had no effect on IgG1 levels at day 7 postinfection and actually enhanced levels at day 10. Decreases in IgM levels were observed in anti-IL-4-treated mice. Administration of anti-IL-5 inhibited IgM production early in infection, but no effects on IgG1 levels were observed. Treatment of infected mice with anti-gamma interferon had no effect on any of the isotypes analyzed. Treatment of infected mice with anti-IL-6 antibody had the most dramatic effects, with inhibition of IgM and IgG1 by day 14 of infection. The transient expression of IgG3, which is sometimes observed very early in the infection process, was also inhibited by anti-IL-6, suggesting that the inhibition observed was not isotype specific. To determine whether cytokines were acting in concert to effect the high IgM and IgG1 levels in infected animals, anticytokine antibodies were also injected in combinations. However, the only combinations that inhibited IgG1 levels contained anti-IL-6, and the extent of inhibition was not greater than that of anti-IL-6 alone. Results are discussed in terms of the effects of cytokines on parasite-induced isotype expression and the potential for IL-4-independent mechanisms of IgG1 production." @default.
• W2110270306 created "2016-06-24" @default.
• W2110270306 creator A5051584890 @default.
• W2110270306 creator A5064151448 @default.
• W2110270306 date "1991-03-01" @default.
• W2110270306 modified "2023-10-17" @default.
• W2110270306 title "In vivo effects of anticytokine antibodies on isotype restriction in Mesocestoides corti-infected BALB/c mice" @default.
• W2110270306 cites W1596476497 @default.
• W2110270306 cites W1867533334 @default.
• W2110270306 cites W1964347128 @default.
• W2110270306 cites W1966037431 @default.
• W2110270306 cites W1970854796 @default.
• W2110270306 cites W1984915036 @default.
• W2110270306 cites W1995471726 @default.
• W2110270306 cites W2000637851 @default.
• W2110270306 cites W2010293484 @default.
• W2110270306 cites W2013571259 @default.
• W2110270306 cites W2016493554 @default.
• W2110270306 cites W2027366621 @default.
• W2110270306 cites W2041647537 @default.
• W2110270306 cites W2041765961 @default.
• W2110270306 cites W2047780915 @default.
• W2110270306 cites W2059817127 @default.
• W2110270306 cites W2060912271 @default.
• W2110270306 cites W2062878033 @default.
• W2110270306 cites W2072490043 @default.
• W2110270306 cites W2073023385 @default.
• W2110270306 cites W2093387446 @default.
• W2110270306 cites W2121186714 @default.
• W2110270306 cites W2121458534 @default.
• W2110270306 cites W2124086093 @default.
• W2110270306 cites W2127278205 @default.
• W2110270306 cites W2129085373 @default.
• W2110270306 cites W2135392289 @default.
• W2110270306 cites W2156619629 @default.
• W2110270306 cites W2168822788 @default.
• W2110270306 cites W2172466148 @default.
• W2110270306 cites W2177385981 @default.
• W2110270306 cites W2225120452 @default.
• W2110270306 cites W2485496237 @default.
• W2110270306 cites W285285269 @default.
• W2110270306 doi "https://doi.org/10.1128/iai.59.3.836-842.1991" @default.
• W2110270306 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/258335" @default.
• W2110270306 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1997434" @default.
• W2110270306 hasPublicationYear "1991" @default.
• W2110270306 type Work @default.
• W2110270306 sameAs 2110270306 @default.
• W2110270306 citedByCount "13" @default.
• W2110270306 countsByYear W21102703062016 @default.
• W2110270306 countsByYear W21102703062020 @default.
• W2110270306 crossrefType "journal-article" @default.
• W2110270306 hasAuthorship W2110270306A5051584890 @default.
• W2110270306 hasAuthorship W2110270306A5064151448 @default.
• W2110270306 hasBestOaLocation W21102703061 @default.
• W2110270306 hasConcept C159654299 @default.
• W2110270306 hasConcept C203014093 @default.
• W2110270306 hasConcept C2776180460 @default.
• W2110270306 hasConcept C2776553844 @default.
• W2110270306 hasConcept C2777991845 @default.
• W2110270306 hasConcept C2778690821 @default.
• W2110270306 hasConcept C2780841837 @default.
• W2110270306 hasConcept C2780898057 @default.
• W2110270306 hasConcept C542903549 @default.
• W2110270306 hasConcept C86803240 @default.
• W2110270306 hasConceptScore W2110270306C159654299 @default.
• W2110270306 hasConceptScore W2110270306C203014093 @default.
• W2110270306 hasConceptScore W2110270306C2776180460 @default.
• W2110270306 hasConceptScore W2110270306C2776553844 @default.
• W2110270306 hasConceptScore W2110270306C2777991845 @default.
• W2110270306 hasConceptScore W2110270306C2778690821 @default.
• W2110270306 hasConceptScore W2110270306C2780841837 @default.
• W2110270306 hasConceptScore W2110270306C2780898057 @default.
• W2110270306 hasConceptScore W2110270306C542903549 @default.
• W2110270306 hasConceptScore W2110270306C86803240 @default.
• W2110270306 hasIssue "3" @default.
• W2110270306 hasLocation W21102703061 @default.
• W2110270306 hasLocation W21102703062 @default.
• W2110270306 hasLocation W21102703063 @default.
• W2110270306 hasOpenAccess W2110270306 @default.
• W2110270306 hasPrimaryLocation W21102703061 @default.
• W2110270306 hasRelatedWork W1968932177 @default.
• W2110270306 hasRelatedWork W198501336 @default.
• W2110270306 hasRelatedWork W1989324573 @default.
• W2110270306 hasRelatedWork W2001986012 @default.
• W2110270306 hasRelatedWork W2006671996 @default.
• W2110270306 hasRelatedWork W2011097336 @default.
• W2110270306 hasRelatedWork W2023668184 @default.
• W2110270306 hasRelatedWork W2028307988 @default.
• W2110270306 hasRelatedWork W2030247443 @default.
• W2110270306 hasRelatedWork W2063557860 @default.
• W2110270306 hasRelatedWork W2064471982 @default.
• W2110270306 hasRelatedWork W2086217776 @default.
• W2110270306 hasRelatedWork W2090598598 @default.
• W2110270306 hasRelatedWork W2101932399 @default.
• W2110270306 hasRelatedWork W2159630219 @default.
• W2110270306 hasRelatedWork W2174731873 @default.
• W2110270306 hasRelatedWork W2185418044 @default.
• W2110270306 hasRelatedWork W2187221836 @default.

• next