FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2110285564> ?p ?o ?g. }

• W2110285564 endingPage "429" @default.
• W2110285564 startingPage "422" @default.
• W2110285564 abstract "Invasion and metastasis is the main cause of cancer mortality. Angiogenesis is a prerequisite for the tumor growth and metastasis. Matrix metalloproteinases (MMPs) are the key enzymes playing in the invasive growth and metastasis of cancer as well as angiogenesis. Xanthohumol, a prenylated chalcone of the Hop plant (Humulus lupulus L), has been reported to suppress cancer invasion and angiogenesis. In the present study, we investigated the antiinvasive effects of xanthohumol (1) and its synthetic derivatives, 4'-O-methylxanthohumol SEM ether (2), xanthohumol C (3), and xanthohumol C MOM ether (4) in relation to MMP expression in HT-1080 human fibrosarcoma cells. The compound 1 and its derivative, 3 and 4, significantly inhibited serum-induced HT-1080 cell invasion, and 12-O-tetradecanoylphorbol-13-acetate (TPA)-enhanced activity and expression level of MMP-2 and MMP-9 in a concentration-dependant manner. In addition, they inhibited TPA-enhanced expression of MT1-MMP with relatively weak inhibition in tissue inhibitor of metalloproteinase (TIMP)-1 and TIMP-2 level. The compound 1 significantly decreased the cell viability, whereas the derivatives, 2 and 3 showed no cytotoxicity, and compound 4 showed slight cytotoxicity in the cells. Furthermore, in a chick chorioallantoic membrane (CAM) assay, the derivatives 3 and 4 dose-dependently suppressed vascular endothelial growth factor (VEGF)-induced angiogenesis, which is similar to that of compound 1. Taken together, the results indicate that compounds 3 and 4 may be valuable anti-angiogenic agents in the treatment of chronic diseases such as cancer and inflammation working through suppression of MMP-2 and MMP-9." @default.
• W2110285564 created "2016-06-24" @default.
• W2110285564 creator A5004746768 @default.
• W2110285564 creator A5043681347 @default.
• W2110285564 creator A5048145361 @default.
• W2110285564 creator A5070142225 @default.
• W2110285564 creator A5080707196 @default.
• W2110285564 creator A5088749815 @default.
• W2110285564 creator A5088869871 @default.
• W2110285564 creator A5089341423 @default.
• W2110285564 date "2009-10-31" @default.
• W2110285564 modified "2023-09-27" @default.
• W2110285564 title "Anti-Invasive and Anti-Angiogenic Effects of Xanthohumol and Its Synthetic Derivatives" @default.
• W2110285564 cites W1571077582 @default.
• W2110285564 cites W1969101538 @default.
• W2110285564 cites W1970406868 @default.
• W2110285564 cites W1971056168 @default.
• W2110285564 cites W1972612011 @default.
• W2110285564 cites W1975176400 @default.
• W2110285564 cites W1977557850 @default.
• W2110285564 cites W1994250572 @default.
• W2110285564 cites W2010056601 @default.
• W2110285564 cites W2011875859 @default.
• W2110285564 cites W2040467812 @default.
• W2110285564 cites W2049669401 @default.
• W2110285564 cites W2051961864 @default.
• W2110285564 cites W2054944999 @default.
• W2110285564 cites W2057896496 @default.
• W2110285564 cites W2063737564 @default.
• W2110285564 cites W2076216347 @default.
• W2110285564 cites W2080591905 @default.
• W2110285564 cites W2083438409 @default.
• W2110285564 cites W2087966918 @default.
• W2110285564 cites W2093853271 @default.
• W2110285564 cites W2099175360 @default.
• W2110285564 cites W2106319388 @default.
• W2110285564 cites W2122171821 @default.
• W2110285564 cites W2146278165 @default.
• W2110285564 cites W2153724103 @default.
• W2110285564 cites W2161308071 @default.
• W2110285564 cites W309980051 @default.
• W2110285564 cites W4235022528 @default.
• W2110285564 doi "https://doi.org/10.4062/biomolther.2009.17.4.422" @default.
• W2110285564 hasPublicationYear "2009" @default.
• W2110285564 type Work @default.
• W2110285564 sameAs 2110285564 @default.
• W2110285564 citedByCount "10" @default.
• W2110285564 countsByYear W21102855642013 @default.
• W2110285564 countsByYear W21102855642014 @default.
• W2110285564 countsByYear W21102855642017 @default.
• W2110285564 countsByYear W21102855642018 @default.
• W2110285564 countsByYear W21102855642020 @default.
• W2110285564 countsByYear W21102855642021 @default.
• W2110285564 countsByYear W21102855642022 @default.
• W2110285564 crossrefType "journal-article" @default.
• W2110285564 hasAuthorship W2110285564A5004746768 @default.
• W2110285564 hasAuthorship W2110285564A5043681347 @default.
• W2110285564 hasAuthorship W2110285564A5048145361 @default.
• W2110285564 hasAuthorship W2110285564A5070142225 @default.
• W2110285564 hasAuthorship W2110285564A5080707196 @default.
• W2110285564 hasAuthorship W2110285564A5088749815 @default.
• W2110285564 hasAuthorship W2110285564A5088869871 @default.
• W2110285564 hasAuthorship W2110285564A5089341423 @default.
• W2110285564 hasBestOaLocation W21102855641 @default.
• W2110285564 hasConcept C109316439 @default.
• W2110285564 hasConcept C109523444 @default.
• W2110285564 hasConcept C121608353 @default.
• W2110285564 hasConcept C126322002 @default.
• W2110285564 hasConcept C181199279 @default.
• W2110285564 hasConcept C185592680 @default.
• W2110285564 hasConcept C18903297 @default.
• W2110285564 hasConcept C202751555 @default.
• W2110285564 hasConcept C26517878 @default.
• W2110285564 hasConcept C2779013556 @default.
• W2110285564 hasConcept C2779642036 @default.
• W2110285564 hasConcept C2779682216 @default.
• W2110285564 hasConcept C2779719074 @default.
• W2110285564 hasConcept C2779765511 @default.
• W2110285564 hasConcept C2780394083 @default.
• W2110285564 hasConcept C502942594 @default.
• W2110285564 hasConcept C55493867 @default.
• W2110285564 hasConcept C71924100 @default.
• W2110285564 hasConcept C86803240 @default.
• W2110285564 hasConcept C96232424 @default.
• W2110285564 hasConcept C97230052 @default.
• W2110285564 hasConcept C98274493 @default.
• W2110285564 hasConceptScore W2110285564C109316439 @default.
• W2110285564 hasConceptScore W2110285564C109523444 @default.
• W2110285564 hasConceptScore W2110285564C121608353 @default.
• W2110285564 hasConceptScore W2110285564C126322002 @default.
• W2110285564 hasConceptScore W2110285564C181199279 @default.
• W2110285564 hasConceptScore W2110285564C185592680 @default.
• W2110285564 hasConceptScore W2110285564C18903297 @default.
• W2110285564 hasConceptScore W2110285564C202751555 @default.
• W2110285564 hasConceptScore W2110285564C26517878 @default.
• W2110285564 hasConceptScore W2110285564C2779013556 @default.
• W2110285564 hasConceptScore W2110285564C2779642036 @default.
• W2110285564 hasConceptScore W2110285564C2779682216 @default.

• next