Matches in SemOpenAlex for { <https://semopenalex.org/work/W2110285576> ?p ?o ?g. }
- W2110285576 endingPage "855" @default.
- W2110285576 startingPage "847" @default.
- W2110285576 abstract "Abstract Cancer cells accumulate widespread local and global chromatin changes and the source of this instability remains a key question. Here we hypothesize that chromatin alterations including unscheduled silencing can arise as a consequence of perturbed histone dynamics in response to replication stress. Chromatin organization is transiently disrupted during DNA replication and maintenance of epigenetic information thus relies on faithful restoration of chromatin on the new daughter strands. Acute replication stress challenges proper chromatin restoration by deregulating histone H3 lysine 9 mono‐methylation on new histones and impairing parental histone recycling. This could facilitate stochastic epigenetic silencing by laying down repressive histone marks at sites of fork stalling. Deregulation of replication in response to oncogenes and other tumor‐promoting insults is recognized as a significant source of genome instability in cancer. We propose that replication stress not only presents a threat to genome stability, but also jeopardizes chromatin integrity and increases epigenetic plasticity during tumorigenesis." @default.
- W2110285576 created "2016-06-24" @default.
- W2110285576 creator A5067308414 @default.
- W2110285576 creator A5087145202 @default.
- W2110285576 date "2010-08-19" @default.
- W2110285576 modified "2023-10-16" @default.
- W2110285576 title "Replication stress, a source of epigenetic aberrations in cancer?" @default.
- W2110285576 cites W1504303645 @default.
- W2110285576 cites W1512281455 @default.
- W2110285576 cites W1569755992 @default.
- W2110285576 cites W1652583010 @default.
- W2110285576 cites W1963851622 @default.
- W2110285576 cites W1965341449 @default.
- W2110285576 cites W1967224500 @default.
- W2110285576 cites W1967232610 @default.
- W2110285576 cites W1969670934 @default.
- W2110285576 cites W1970304959 @default.
- W2110285576 cites W1970592702 @default.
- W2110285576 cites W1970640134 @default.
- W2110285576 cites W1970821439 @default.
- W2110285576 cites W1970924670 @default.
- W2110285576 cites W1973279069 @default.
- W2110285576 cites W1973549360 @default.
- W2110285576 cites W1974784924 @default.
- W2110285576 cites W1977621555 @default.
- W2110285576 cites W1982395176 @default.
- W2110285576 cites W1982966836 @default.
- W2110285576 cites W1983921161 @default.
- W2110285576 cites W1984795661 @default.
- W2110285576 cites W1985188792 @default.
- W2110285576 cites W1985634754 @default.
- W2110285576 cites W1989068609 @default.
- W2110285576 cites W1989410686 @default.
- W2110285576 cites W1990381590 @default.
- W2110285576 cites W1998415606 @default.
- W2110285576 cites W1998418245 @default.
- W2110285576 cites W2001468176 @default.
- W2110285576 cites W2002191009 @default.
- W2110285576 cites W2007684630 @default.
- W2110285576 cites W2007980721 @default.
- W2110285576 cites W2009121506 @default.
- W2110285576 cites W2013081982 @default.
- W2110285576 cites W2013167125 @default.
- W2110285576 cites W2014766736 @default.
- W2110285576 cites W2017308570 @default.
- W2110285576 cites W2019276374 @default.
- W2110285576 cites W2020246476 @default.
- W2110285576 cites W2022893562 @default.
- W2110285576 cites W2024218777 @default.
- W2110285576 cites W2024373518 @default.
- W2110285576 cites W2026377072 @default.
- W2110285576 cites W2029197798 @default.
- W2110285576 cites W2029484950 @default.
- W2110285576 cites W2034979835 @default.
- W2110285576 cites W2036986058 @default.
- W2110285576 cites W2039408641 @default.
- W2110285576 cites W2041156660 @default.
- W2110285576 cites W2042087070 @default.
- W2110285576 cites W2044427708 @default.
- W2110285576 cites W2044721366 @default.
- W2110285576 cites W2045650289 @default.
- W2110285576 cites W2056145665 @default.
- W2110285576 cites W2059971436 @default.
- W2110285576 cites W2062093164 @default.
- W2110285576 cites W2063979868 @default.
- W2110285576 cites W2064297857 @default.
- W2110285576 cites W2065437731 @default.
- W2110285576 cites W2065891752 @default.
- W2110285576 cites W2066663722 @default.
- W2110285576 cites W2067117191 @default.
- W2110285576 cites W2070582215 @default.
- W2110285576 cites W2072155586 @default.
- W2110285576 cites W2072659475 @default.
- W2110285576 cites W2072747624 @default.
- W2110285576 cites W2072762966 @default.
- W2110285576 cites W2073759231 @default.
- W2110285576 cites W2076170552 @default.
- W2110285576 cites W2076684722 @default.
- W2110285576 cites W2078281194 @default.
- W2110285576 cites W2079803074 @default.
- W2110285576 cites W2082559623 @default.
- W2110285576 cites W2082592723 @default.
- W2110285576 cites W2083245183 @default.
- W2110285576 cites W2086333179 @default.
- W2110285576 cites W2086516583 @default.
- W2110285576 cites W2089689396 @default.
- W2110285576 cites W2091884937 @default.
- W2110285576 cites W2092761963 @default.
- W2110285576 cites W2093364695 @default.
- W2110285576 cites W2096330673 @default.
- W2110285576 cites W2096707410 @default.
- W2110285576 cites W2098549100 @default.
- W2110285576 cites W2100097357 @default.
- W2110285576 cites W2100543217 @default.
- W2110285576 cites W2100894466 @default.
- W2110285576 cites W2101139969 @default.
- W2110285576 cites W2101370480 @default.
- W2110285576 cites W2105617035 @default.