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- W2110286409 startingPage "159" @default.
- W2110286409 abstract "Post-operative atrial fibrillation (POAF) is one of the most frequent complications of cardiac surgery and an important predictor of patient morbidity as well as of prolonged hospitalization. It significantly increases costs for hospitalization. Insights into the pathophysiological factors causing POAF have been provided by both experimental and clinical investigations and show that POAF is ‘multi-factorial’. Facilitating factors in the mechanism of the arrhythmia can be classified as acute factors caused by the surgical intervention and chronic factors related to structural heart disease and ageing of the heart. Furthermore, some proarrhythmic mechanisms specifically occur in the setting of POAF. For example, inflammation and beta-adrenergic activation have been shown to play a prominent role in POAF, while these mechanisms are less important in non-surgical AF. More recently, it has been shown that atrial fibrosis and the presence of an electrophysiological substrate capable of maintaining AF also promote the arrhythmia, indicating that POAF has some proarrhythmic mechanisms in common with other forms of AF. The clinical setting of POAF offers numerous opportunities to study its mechanisms. During cardiac surgery, biopsies can be taken and detailed electrophysiological measurements can be performed. Furthermore, the specific time course of POAF, with the delayed onset and the transient character of the arrhythmia, also provides important insight into its mechanisms. This review discusses the mechanistic interaction between predisposing factors and the electrophysiological mechanisms resulting in POAF and their therapeutic implications." @default.
- W2110286409 created "2016-06-24" @default.
- W2110286409 creator A5016545357 @default.
- W2110286409 creator A5031776037 @default.
- W2110286409 creator A5046773983 @default.
- W2110286409 creator A5088308248 @default.
- W2110286409 creator A5090060143 @default.
- W2110286409 date "2011-08-06" @default.
- W2110286409 modified "2023-10-14" @default.
- W2110286409 title "Post-operative atrial fibrillation: a maze of mechanisms" @default.
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