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- W2110289042 abstract "Homeostatic regulation of T cells involves an ongoing balance of new T cell generation, peripheral expansion, and turnover. The recovery of T cells when this balance is disrupted provides insight into the mechanisms that govern homeostasis. In a long-term, single cohort study, we assessed the role of thymic function after autologous transplant in adults, correlating serial computed tomography imaging of thymic size with concurrent measurements of peripheral CD4+ T cell populations. We established the age-dependent incidence, time course, and duration of thymic enlargement in adults and demonstrated that these changes were correlated with peripheral recovery of naive CD45RA+CD62L+ and signal-joint TCR rearrangement excision circle–bearing CD4+ populations with broad TCR diversity. Furthermore, we demonstrated that renewed thymopoiesis was critical for the restoration of peripheral CD4+ T cell populations. This recovery encompassed the recovery of normal CD4+ T cell numbers, a low ratio of effector to central memory cells, and a broad repertoire of TCR Vβ diversity among these memory cells. These data define the timeline and consequences of renewal of adult thymopoietic activity at levels able to quantitatively restore peripheral T cell populations. They further suggest that structural thymic regrowth serves as a basis for the regeneration of peripheral T cell populations." @default.
- W2110289042 created "2016-06-24" @default.
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- W2110289042 date "2005-03-17" @default.
- W2110289042 modified "2023-10-12" @default.
- W2110289042 title "Age-dependent incidence, time course, and consequences of thymic renewal in adults" @default.
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- W2110289042 doi "https://doi.org/10.1172/jci200522492" @default.
- W2110289042 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1064981" @default.
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