FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2110292281> ?p ?o ?g. }

• W2110292281 endingPage "634" @default.
• W2110292281 startingPage "627" @default.
• W2110292281 abstract "This study was designed to investigate the potential effect of bergapten on lipopolysaccharide (LPS)-mediated osteoclast formation, bone resorption and osteoclast survival in vitro. After osteoclast precursor RAW264.7 cells were treated with bergapten (5, 20, 40 μmol/L) for 72 hours in the presence of LPS (100 ng/ml), osteoclastogenesis was identified by tartrate-resistant acid phosphatase (TRAP) staining, and the number of TRAP-positive multinucleated cells [TRAP(+)MNCs] per well were counted. To investigate the effect of bergapten on osteoclastic bone resorption, RAW264.7 cells were treated with bergapten for six days in the presence of LPS, and the area of bone resorption was analyzed with Image Pro-Plus. Next, we examined apoptosis of RAW264.7 cells after bergapten incubation for 48 hours by flow cytometer using annexin V/propidium iodide (PI) double labeling. Finally, osteoclast survival was observed by Hoechst 33342 labeling and Western blotting after bergapten treatment for 24 hours. Data showed that bergapten (5–40 μmol/L) dose-dependently inhibited LPS-induced osteoclast formation and bone resorption. Treatment with bergapten triggered apoptotic death of osteoclast precursor RAW264.7 cells in a dose-dependent manner. Furthermore, bergapten significantly reduced the survival of mature osteoclast, as demonstrated by emergence of apoptotic nuclei and activation of apoptotic protein caspase 3/9. These findings suggest that bergapten effectively prevents LPS-induced osteoclastogenesis, bone resorption and survival via apoptotic response of osteoclasts and their precursors. The study identifies bergapten as an inhibitor of osteoclast formation and bone resorption and provides evidence that bergapten might be beneficial as an alternative for prevention and treatment of inflammatory bone loss." @default.
• W2110292281 created "2016-06-24" @default.
• W2110292281 creator A5005205839 @default.
• W2110292281 creator A5023874610 @default.
• W2110292281 creator A5025854267 @default.
• W2110292281 creator A5036921449 @default.
• W2110292281 creator A5085539550 @default.
• W2110292281 creator A5088150665 @default.
• W2110292281 date "2013-12-04" @default.
• W2110292281 modified "2023-10-01" @default.
• W2110292281 title "Bergapten prevents lipopolysaccharide mediated osteoclast formation, bone resorption and osteoclast survival" @default.
• W2110292281 cites W1522615306 @default.
• W2110292281 cites W1585793353 @default.
• W2110292281 cites W1965545325 @default.
• W2110292281 cites W1982014036 @default.
• W2110292281 cites W1982375154 @default.
• W2110292281 cites W1999235557 @default.
• W2110292281 cites W2038378875 @default.
• W2110292281 cites W2039701198 @default.
• W2110292281 cites W2043022153 @default.
• W2110292281 cites W2043052287 @default.
• W2110292281 cites W2048141414 @default.
• W2110292281 cites W2055377154 @default.
• W2110292281 cites W2056925010 @default.
• W2110292281 cites W2085280130 @default.
• W2110292281 cites W2089122678 @default.
• W2110292281 cites W2092680402 @default.
• W2110292281 cites W2110997512 @default.
• W2110292281 cites W2135438467 @default.
• W2110292281 cites W2145385610 @default.
• W2110292281 cites W2162621845 @default.
• W2110292281 doi "https://doi.org/10.1007/s00264-013-2184-y" @default.
• W2110292281 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3936084" @default.
• W2110292281 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24305787" @default.
• W2110292281 hasPublicationYear "2013" @default.
• W2110292281 type Work @default.
• W2110292281 sameAs 2110292281 @default.
• W2110292281 citedByCount "29" @default.
• W2110292281 countsByYear W21102922812015 @default.
• W2110292281 countsByYear W21102922812016 @default.
• W2110292281 countsByYear W21102922812017 @default.
• W2110292281 countsByYear W21102922812018 @default.
• W2110292281 countsByYear W21102922812019 @default.
• W2110292281 countsByYear W21102922812020 @default.
• W2110292281 countsByYear W21102922812021 @default.
• W2110292281 countsByYear W21102922812022 @default.
• W2110292281 countsByYear W21102922812023 @default.
• W2110292281 crossrefType "journal-article" @default.
• W2110292281 hasAuthorship W2110292281A5005205839 @default.
• W2110292281 hasAuthorship W2110292281A5023874610 @default.
• W2110292281 hasAuthorship W2110292281A5025854267 @default.
• W2110292281 hasAuthorship W2110292281A5036921449 @default.
• W2110292281 hasAuthorship W2110292281A5085539550 @default.
• W2110292281 hasAuthorship W2110292281A5088150665 @default.
• W2110292281 hasBestOaLocation W21102922812 @default.
• W2110292281 hasConcept C126322002 @default.
• W2110292281 hasConcept C136403682 @default.
• W2110292281 hasConcept C142724271 @default.
• W2110292281 hasConcept C146562846 @default.
• W2110292281 hasConcept C153911025 @default.
• W2110292281 hasConcept C170493617 @default.
• W2110292281 hasConcept C185592680 @default.
• W2110292281 hasConcept C190283241 @default.
• W2110292281 hasConcept C2776033226 @default.
• W2110292281 hasConcept C2777307396 @default.
• W2110292281 hasConcept C2781110370 @default.
• W2110292281 hasConcept C502942594 @default.
• W2110292281 hasConcept C552990157 @default.
• W2110292281 hasConcept C55493867 @default.
• W2110292281 hasConcept C673006 @default.
• W2110292281 hasConcept C71924100 @default.
• W2110292281 hasConcept C86803240 @default.
• W2110292281 hasConceptScore W2110292281C126322002 @default.
• W2110292281 hasConceptScore W2110292281C136403682 @default.
• W2110292281 hasConceptScore W2110292281C142724271 @default.
• W2110292281 hasConceptScore W2110292281C146562846 @default.
• W2110292281 hasConceptScore W2110292281C153911025 @default.
• W2110292281 hasConceptScore W2110292281C170493617 @default.
• W2110292281 hasConceptScore W2110292281C185592680 @default.
• W2110292281 hasConceptScore W2110292281C190283241 @default.
• W2110292281 hasConceptScore W2110292281C2776033226 @default.
• W2110292281 hasConceptScore W2110292281C2777307396 @default.
• W2110292281 hasConceptScore W2110292281C2781110370 @default.
• W2110292281 hasConceptScore W2110292281C502942594 @default.
• W2110292281 hasConceptScore W2110292281C552990157 @default.
• W2110292281 hasConceptScore W2110292281C55493867 @default.
• W2110292281 hasConceptScore W2110292281C673006 @default.
• W2110292281 hasConceptScore W2110292281C71924100 @default.
• W2110292281 hasConceptScore W2110292281C86803240 @default.
• W2110292281 hasIssue "3" @default.
• W2110292281 hasLocation W21102922811 @default.
• W2110292281 hasLocation W21102922812 @default.
• W2110292281 hasLocation W21102922813 @default.
• W2110292281 hasLocation W21102922814 @default.
• W2110292281 hasOpenAccess W2110292281 @default.
• W2110292281 hasPrimaryLocation W21102922811 @default.
• W2110292281 hasRelatedWork W1985885388 @default.
• W2110292281 hasRelatedWork W1990428395 @default.

• next