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- W2110293702 abstract "Purpose: To compare the incidence of inflammatory giant-cell deposits (IGCDs) on various foldable intraocular lenses (IOLs) after combined cataract and glaucoma surgery. Setting: The Phillips Eye Institute, Minneapolis, Minnesota, USA. Methods: In this prospective randomized clinical trial, 128 patients were randomized to receive a single-piece, first-generation silicone lens (n = 36); a 3-piece acrylic lens (n = 40); or 3-piece, second-generation silicone lens (n = 52). All patients had combined phacoemulsification and trabeculectomy with mitomycin-C by 1 surgeon using a standardized technique. Dilated biomicroscopy was used to identify and quantitate IGCDs on the surface of the IOLs using a 6-point grading scale. Results: Inflammatory giant-cell deposits were identified on 21 of 128 IOLs. Lens design was the most significant risk factor for deposit formation (P = .004). Inflammatory giant-cell deposits were most common in the first-generation silicone plate lens group (33%), less common in the acrylic lens group (15%), and least common in the 3-piece, second-generation silicone group (5.8%). Density of the deposits was significantly greater on the plate lens than the acrylic or the 3-piece silicone lenses (P < .0001). Although IOL design was the most significant risk factor for IGCD formation, other significant risk factors included intraoperative pupil stretch (P = .02) and preoperative miotic use (P = .04). Conclusion: Inflammatory giant-cell deposit formation was significantly greater on first-generation silicone plate IOLs than on acrylic or second-generation silicone IOLs. The deposits were somewhat more common on acrylic IOLs than on second-generation silicone IOLs. However, this difference was not clinically or statistically significant." @default.
- W2110293702 created "2016-06-24" @default.
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- W2110293702 date "2000-06-01" @default.
- W2110293702 modified "2023-10-14" @default.
- W2110293702 title "Evaluation of giant-cell deposits on foldable intraocular lenses after combined cataract and glaucoma surgery" @default.
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- W2110293702 doi "https://doi.org/10.1016/s0886-3350(00)00308-4" @default.
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