FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2110293841> ?p ?o ?g. }

• W2110293841 endingPage "2086" @default.
• W2110293841 startingPage "2079" @default.
• W2110293841 abstract "A relationship between nelfinavir antiretroviral efficacy and plasma concentrations has been previously established. As physiological changes associated with pregnancy have a large impact on the pharmacokinetics of many drugs, a nelfinavir population study with women was developed, and the large intersubject variability was analyzed in order to optimize individual treatment schedules for this drug during pregnancy. A population pharmacokinetic model was developed in order to describe the concentration time course of nelfinavir and its metabolite M8 in pregnant and nonpregnant women. Individual characteristics, such as age, body weight, and weeks of gestation or delivery, which may influence nelfinavir-M8 pharmacokinetics were investigated. Data from therapeutic drug monitoring in 133 women treated with nelfinavir were retrospectively analyzed with NONMEM. Nelfinavir pharmacokinetics was described by a one-compartment model with linear absorption and elimination and M8 produced from the nelfinavir central compartment. Mean pharmacokinetic estimates and the corresponding intersubject percent variabilities for a nonpregnant woman were the following: absorption rate, 0.83 h(-1); absorption lag time, 0.85 h; apparent nelfinavir elimination clearance (CL(10)/F), 35.5 liters/h (50%); apparent volume of distribution (V/F), 596 liters (118%); apparent formation clearance to M8 (CL(1M)/F), 0.65 liters/h (69%); and M8 elimination rate constant (k(M0)), 3.3 h(-1) (59%). During pregnancy, we observed significant increases in nelfinavir (44.4 liters/h) and M8 (5 h(-1)) elimination but unchanged nelfinavir transformation clearance to M8, suggesting an induction of CYP3A4 but no effect on CYP2C19. Apparent nelfinavir clearance and volume showed a twofold increase on the day of delivery, suggesting a decrease in bioavailability on this day. The M8 elimination rate was increased by concomitant administration of nonnucleoside reverse transcriptase inhibitors. A trough nelfinavir plasma concentration above 1 mg/liter was previously shown to improve the antiretroviral response. The Bayesian individual pharmacokinetic estimates suggested that the dosage should not be changed in pregnant women but may be doubled on the day of delivery." @default.
• W2110293841 created "2016-06-24" @default.
• W2110293841 creator A5010654547 @default.
• W2110293841 creator A5016638923 @default.
• W2110293841 creator A5036481508 @default.
• W2110293841 creator A5036742391 @default.
• W2110293841 creator A5037696502 @default.
• W2110293841 creator A5040559085 @default.
• W2110293841 creator A5045654612 @default.
• W2110293841 creator A5048792225 @default.
• W2110293841 creator A5077853084 @default.
• W2110293841 date "2006-06-01" @default.
• W2110293841 modified "2023-09-30" @default.
• W2110293841 title "Pregnancy-Related Effects on Nelfinavir-M8 Pharmacokinetics: a Population Study with 133 Women" @default.
• W2110293841 cites W105671925 @default.
• W2110293841 cites W1985059525 @default.
• W2110293841 cites W1999449749 @default.
• W2110293841 cites W2002098693 @default.
• W2110293841 cites W2010411643 @default.
• W2110293841 cites W2038025308 @default.
• W2110293841 cites W2059341439 @default.
• W2110293841 cites W2059536444 @default.
• W2110293841 cites W2067065001 @default.
• W2110293841 cites W2080008894 @default.
• W2110293841 cites W2106684789 @default.
• W2110293841 cites W2107639362 @default.
• W2110293841 cites W2110222367 @default.
• W2110293841 cites W2118020412 @default.
• W2110293841 cites W2123052686 @default.
• W2110293841 cites W2124874141 @default.
• W2110293841 cites W2155608888 @default.
• W2110293841 cites W2161446377 @default.
• W2110293841 cites W2163203978 @default.
• W2110293841 cites W2164575685 @default.
• W2110293841 cites W2321838878 @default.
• W2110293841 cites W2324423605 @default.
• W2110293841 doi "https://doi.org/10.1128/aac.01596-05" @default.
• W2110293841 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1479099" @default.
• W2110293841 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16723569" @default.
• W2110293841 hasPublicationYear "2006" @default.
• W2110293841 type Work @default.
• W2110293841 sameAs 2110293841 @default.
• W2110293841 citedByCount "35" @default.
• W2110293841 countsByYear W21102938412012 @default.
• W2110293841 countsByYear W21102938412013 @default.
• W2110293841 countsByYear W21102938412014 @default.
• W2110293841 countsByYear W21102938412015 @default.
• W2110293841 countsByYear W21102938412016 @default.
• W2110293841 countsByYear W21102938412017 @default.
• W2110293841 countsByYear W21102938412018 @default.
• W2110293841 countsByYear W21102938412020 @default.
• W2110293841 countsByYear W21102938412022 @default.
• W2110293841 crossrefType "journal-article" @default.
• W2110293841 hasAuthorship W2110293841A5010654547 @default.
• W2110293841 hasAuthorship W2110293841A5016638923 @default.
• W2110293841 hasAuthorship W2110293841A5036481508 @default.
• W2110293841 hasAuthorship W2110293841A5036742391 @default.
• W2110293841 hasAuthorship W2110293841A5037696502 @default.
• W2110293841 hasAuthorship W2110293841A5040559085 @default.
• W2110293841 hasAuthorship W2110293841A5045654612 @default.
• W2110293841 hasAuthorship W2110293841A5048792225 @default.
• W2110293841 hasAuthorship W2110293841A5077853084 @default.
• W2110293841 hasBestOaLocation W21102938412 @default.
• W2110293841 hasConcept C112705442 @default.
• W2110293841 hasConcept C139254425 @default.
• W2110293841 hasConcept C142462285 @default.
• W2110293841 hasConcept C203014093 @default.
• W2110293841 hasConcept C2776239304 @default.
• W2110293841 hasConcept C2781160516 @default.
• W2110293841 hasConcept C2908647359 @default.
• W2110293841 hasConcept C2993143319 @default.
• W2110293841 hasConcept C3013748606 @default.
• W2110293841 hasConcept C71924100 @default.
• W2110293841 hasConcept C98274493 @default.
• W2110293841 hasConcept C99454951 @default.
• W2110293841 hasConceptScore W2110293841C112705442 @default.
• W2110293841 hasConceptScore W2110293841C139254425 @default.
• W2110293841 hasConceptScore W2110293841C142462285 @default.
• W2110293841 hasConceptScore W2110293841C203014093 @default.
• W2110293841 hasConceptScore W2110293841C2776239304 @default.
• W2110293841 hasConceptScore W2110293841C2781160516 @default.
• W2110293841 hasConceptScore W2110293841C2908647359 @default.
• W2110293841 hasConceptScore W2110293841C2993143319 @default.
• W2110293841 hasConceptScore W2110293841C3013748606 @default.
• W2110293841 hasConceptScore W2110293841C71924100 @default.
• W2110293841 hasConceptScore W2110293841C98274493 @default.
• W2110293841 hasConceptScore W2110293841C99454951 @default.
• W2110293841 hasIssue "6" @default.
• W2110293841 hasLocation W21102938411 @default.
• W2110293841 hasLocation W21102938412 @default.
• W2110293841 hasLocation W21102938413 @default.
• W2110293841 hasLocation W21102938414 @default.
• W2110293841 hasOpenAccess W2110293841 @default.
• W2110293841 hasPrimaryLocation W21102938411 @default.
• W2110293841 hasRelatedWork W10390674 @default.
• W2110293841 hasRelatedWork W2020252702 @default.
• W2110293841 hasRelatedWork W2029534057 @default.
• W2110293841 hasRelatedWork W2066751683 @default.

• next