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• W2110294577 abstract "Following the discovery that hydroxylated derivative 3 (Fig. 1) was one of the oxidative metabolites of the original lead 1, it was found that hydroxylated compound 4 possesses higher in vitro anti-HIV potency than the corresponding non-hydroxylated compound 2. Structural hybridation of 4 with the orally available analog 5 resulted in another orally-available spirodiketopiperazine CCR5 antagonist 6a that possesses more favorable pharmaceutical profile for use as a drug candidate." @default.
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• W2110294577 date "2011-02-01" @default.
• W2110294577 modified "2023-10-11" @default.
• W2110294577 title "Spirodiketopiperazine-based CCR5 antagonist: Discovery of an antiretroviral drug candidate" @default.
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• W2110294577 doi "https://doi.org/10.1016/j.bmcl.2010.12.109" @default.
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