FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2110294701> ?p ?o ?g. }

• W2110294701 endingPage "7124" @default.
• W2110294701 startingPage "7116" @default.
• W2110294701 abstract "Abstract Complement factor B (fB) is a key constituent of the alternative pathway (AP). Its central role in causing inflammation and tissue injury through activation of the AP urges the need for its therapeutic targeting. In the current study, we have screened phage-displayed random peptide libraries against fB and identified a novel cyclic hendecapeptide that inhibits activation of fB and the AP. Structure-activity studies revealed that: 1) the cysteine-constrained structure of the peptide is essential for its activity; 2) Ile5, Arg6, Leu7, and Tyr8 contribute significantly to its inhibitory activity; and 3) retro-inverso modification of the peptide results in loss of its activity. Binding studies performed using surface plasmon resonance suggested that the peptide has two binding sites on fB, which are located on the Ba and Bb fragments. Studies on the mechanism of inhibition revealed that the peptide does not block the interaction of fB with the activated form of C3, thereby suggesting that the peptide inhibits fB activation primarily by inhibiting its cleavage by factor D. The peptide showed a weak effect on preformed C3 and C5 convertases. Like inhibition of fB cleavage, the peptide also inhibited C2 cleavage by activated C1s and activation of the classical as well as lectin pathways. Based on its inhibitory activities, we named the peptide Complin." @default.
• W2110294701 created "2016-06-24" @default.
• W2110294701 creator A5029043252 @default.
• W2110294701 creator A5064432023 @default.
• W2110294701 date "2010-06-15" @default.
• W2110294701 modified "2023-09-23" @default.
• W2110294701 title "Identification of Complin, a Novel Complement Inhibitor that Targets Complement Proteins Factor B and C2" @default.
• W2110294701 cites W1247518833 @default.
• W2110294701 cites W1489377217 @default.
• W2110294701 cites W1495283560 @default.
• W2110294701 cites W1526236792 @default.
• W2110294701 cites W1546629949 @default.
• W2110294701 cites W1563349777 @default.
• W2110294701 cites W1595283955 @default.
• W2110294701 cites W1659710835 @default.
• W2110294701 cites W1842534109 @default.
• W2110294701 cites W1910602244 @default.
• W2110294701 cites W1970232820 @default.
• W2110294701 cites W1970718615 @default.
• W2110294701 cites W1971204327 @default.
• W2110294701 cites W1983331441 @default.
• W2110294701 cites W1983792126 @default.
• W2110294701 cites W1986428075 @default.
• W2110294701 cites W1993586059 @default.
• W2110294701 cites W1995193732 @default.
• W2110294701 cites W2010717419 @default.
• W2110294701 cites W2013559201 @default.
• W2110294701 cites W2018118709 @default.
• W2110294701 cites W2031147016 @default.
• W2110294701 cites W2036268056 @default.
• W2110294701 cites W2050217807 @default.
• W2110294701 cites W2064918821 @default.
• W2110294701 cites W2080663504 @default.
• W2110294701 cites W2083120327 @default.
• W2110294701 cites W2083388500 @default.
• W2110294701 cites W2094241191 @default.
• W2110294701 cites W2094578643 @default.
• W2110294701 cites W2095322182 @default.
• W2110294701 cites W2117807431 @default.
• W2110294701 cites W2122075336 @default.
• W2110294701 cites W2145478479 @default.
• W2110294701 cites W2150945217 @default.
• W2110294701 cites W2156732183 @default.
• W2110294701 cites W2163295341 @default.
• W2110294701 cites W315197452 @default.
• W2110294701 cites W4300878749 @default.
• W2110294701 doi "https://doi.org/10.4049/jimmunol.1000200" @default.
• W2110294701 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20483772" @default.
• W2110294701 hasPublicationYear "2010" @default.
• W2110294701 type Work @default.
• W2110294701 sameAs 2110294701 @default.
• W2110294701 citedByCount "7" @default.
• W2110294701 countsByYear W21102947012012 @default.
• W2110294701 countsByYear W21102947012017 @default.
• W2110294701 countsByYear W21102947012018 @default.
• W2110294701 countsByYear W21102947012021 @default.
• W2110294701 crossrefType "journal-article" @default.
• W2110294701 hasAuthorship W2110294701A5029043252 @default.
• W2110294701 hasAuthorship W2110294701A5064432023 @default.
• W2110294701 hasBestOaLocation W21102947011 @default.
• W2110294701 hasConcept C106847996 @default.
• W2110294701 hasConcept C111684460 @default.
• W2110294701 hasConcept C14356644 @default.
• W2110294701 hasConcept C151730666 @default.
• W2110294701 hasConcept C155672457 @default.
• W2110294701 hasConcept C159654299 @default.
• W2110294701 hasConcept C171250308 @default.
• W2110294701 hasConcept C175156509 @default.
• W2110294701 hasConcept C179369057 @default.
• W2110294701 hasConcept C185592680 @default.
• W2110294701 hasConcept C189446657 @default.
• W2110294701 hasConcept C192562407 @default.
• W2110294701 hasConcept C203014093 @default.
• W2110294701 hasConcept C2779281246 @default.
• W2110294701 hasConcept C43369102 @default.
• W2110294701 hasConcept C55493867 @default.
• W2110294701 hasConcept C71240020 @default.
• W2110294701 hasConcept C86803240 @default.
• W2110294701 hasConceptScore W2110294701C106847996 @default.
• W2110294701 hasConceptScore W2110294701C111684460 @default.
• W2110294701 hasConceptScore W2110294701C14356644 @default.
• W2110294701 hasConceptScore W2110294701C151730666 @default.
• W2110294701 hasConceptScore W2110294701C155672457 @default.
• W2110294701 hasConceptScore W2110294701C159654299 @default.
• W2110294701 hasConceptScore W2110294701C171250308 @default.
• W2110294701 hasConceptScore W2110294701C175156509 @default.
• W2110294701 hasConceptScore W2110294701C179369057 @default.
• W2110294701 hasConceptScore W2110294701C185592680 @default.
• W2110294701 hasConceptScore W2110294701C189446657 @default.
• W2110294701 hasConceptScore W2110294701C192562407 @default.
• W2110294701 hasConceptScore W2110294701C203014093 @default.
• W2110294701 hasConceptScore W2110294701C2779281246 @default.
• W2110294701 hasConceptScore W2110294701C43369102 @default.
• W2110294701 hasConceptScore W2110294701C55493867 @default.
• W2110294701 hasConceptScore W2110294701C71240020 @default.
• W2110294701 hasConceptScore W2110294701C86803240 @default.
• W2110294701 hasIssue "12" @default.
• W2110294701 hasLocation W21102947011 @default.

• next