Matches in SemOpenAlex for { <https://semopenalex.org/work/W2110296635> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2110296635 endingPage "46" @default.
- W2110296635 startingPage "23" @default.
- W2110296635 abstract "Subtypes of alpha adrenergic receptors were studied using selective adrenergic agonists. A-53693, A-54741, and related compounds were evaluated for their affinity for alpha receptor subtypes using radioligand binding techniques. Efficacy and potency were also evaluated using in vitro bioassays of alpha-1 receptors in rabbit aorta smooth muscle and alpha-2 receptors in the phenoxybenzamine-pretreated canine saphenous vein. Active and inactive compounds were then submitted for computer-assisted molecular modeling evaluation to ascertain the structural requirements for optimal potency and selectivity. Rigid catecholamines such as A-53693 display a high degree of selectivity for alpha-2 compared to alpha-1 receptors, probably because of the unique regions of space at the ligand binding site occupied by active compounds. Imidazolines such as A-54741 also interact with extremely high affinity and potency for alpha-2 receptors, and to a lesser extent at alpha-1 receptors. The spatial domains occupied by phenethylamines and imidazolines differ, each having unique regions of permissable space at alpha receptors. Compounds such as A-53693 and A-54741 are extremely useful probes of the molecular interactions of alpha agonistic compounds which will help in the design of even more selective drugs for alpha adrenergic receptors." @default.
- W2110296635 created "2016-06-24" @default.
- W2110296635 creator A5019204603 @default.
- W2110296635 creator A5027365700 @default.
- W2110296635 creator A5076141903 @default.
- W2110296635 creator A5082377700 @default.
- W2110296635 date "1988-01-01" @default.
- W2110296635 modified "2023-10-16" @default.
- W2110296635 title "Differentiation of Alpha-Adrenergic Receptors Using Pharmacological Evaluation and Molecular Modeling of Selective Adrenergic Agents" @default.
- W2110296635 cites W1521528949 @default.
- W2110296635 cites W1985463748 @default.
- W2110296635 cites W1996972993 @default.
- W2110296635 cites W2001336472 @default.
- W2110296635 cites W2002438359 @default.
- W2110296635 cites W2010702423 @default.
- W2110296635 cites W2013779200 @default.
- W2110296635 cites W2028569155 @default.
- W2110296635 cites W2052325698 @default.
- W2110296635 cites W2065150424 @default.
- W2110296635 cites W2068528858 @default.
- W2110296635 cites W2072990605 @default.
- W2110296635 cites W2089893838 @default.
- W2110296635 cites W2281938476 @default.
- W2110296635 doi "https://doi.org/10.3109/10799898809048976" @default.
- W2110296635 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2898529" @default.
- W2110296635 hasPublicationYear "1988" @default.
- W2110296635 type Work @default.
- W2110296635 sameAs 2110296635 @default.
- W2110296635 citedByCount "14" @default.
- W2110296635 countsByYear W21102966352018 @default.
- W2110296635 countsByYear W21102966352020 @default.
- W2110296635 crossrefType "journal-article" @default.
- W2110296635 hasAuthorship W2110296635A5019204603 @default.
- W2110296635 hasAuthorship W2110296635A5027365700 @default.
- W2110296635 hasAuthorship W2110296635A5076141903 @default.
- W2110296635 hasAuthorship W2110296635A5082377700 @default.
- W2110296635 hasConcept C121528942 @default.
- W2110296635 hasConcept C13348194 @default.
- W2110296635 hasConcept C134018914 @default.
- W2110296635 hasConcept C159110408 @default.
- W2110296635 hasConcept C169331234 @default.
- W2110296635 hasConcept C170493617 @default.
- W2110296635 hasConcept C185592680 @default.
- W2110296635 hasConcept C202751555 @default.
- W2110296635 hasConcept C2775944032 @default.
- W2110296635 hasConcept C2778938600 @default.
- W2110296635 hasConcept C2780668150 @default.
- W2110296635 hasConcept C40465926 @default.
- W2110296635 hasConcept C49453240 @default.
- W2110296635 hasConcept C55493867 @default.
- W2110296635 hasConcept C57992300 @default.
- W2110296635 hasConcept C64943373 @default.
- W2110296635 hasConcept C67847695 @default.
- W2110296635 hasConcept C71924100 @default.
- W2110296635 hasConcept C86803240 @default.
- W2110296635 hasConcept C98274493 @default.
- W2110296635 hasConceptScore W2110296635C121528942 @default.
- W2110296635 hasConceptScore W2110296635C13348194 @default.
- W2110296635 hasConceptScore W2110296635C134018914 @default.
- W2110296635 hasConceptScore W2110296635C159110408 @default.
- W2110296635 hasConceptScore W2110296635C169331234 @default.
- W2110296635 hasConceptScore W2110296635C170493617 @default.
- W2110296635 hasConceptScore W2110296635C185592680 @default.
- W2110296635 hasConceptScore W2110296635C202751555 @default.
- W2110296635 hasConceptScore W2110296635C2775944032 @default.
- W2110296635 hasConceptScore W2110296635C2778938600 @default.
- W2110296635 hasConceptScore W2110296635C2780668150 @default.
- W2110296635 hasConceptScore W2110296635C40465926 @default.
- W2110296635 hasConceptScore W2110296635C49453240 @default.
- W2110296635 hasConceptScore W2110296635C55493867 @default.
- W2110296635 hasConceptScore W2110296635C57992300 @default.
- W2110296635 hasConceptScore W2110296635C64943373 @default.
- W2110296635 hasConceptScore W2110296635C67847695 @default.
- W2110296635 hasConceptScore W2110296635C71924100 @default.
- W2110296635 hasConceptScore W2110296635C86803240 @default.
- W2110296635 hasConceptScore W2110296635C98274493 @default.
- W2110296635 hasIssue "1-4" @default.
- W2110296635 hasLocation W21102966351 @default.
- W2110296635 hasLocation W21102966352 @default.
- W2110296635 hasOpenAccess W2110296635 @default.
- W2110296635 hasPrimaryLocation W21102966351 @default.
- W2110296635 hasRelatedWork W1922812725 @default.
- W2110296635 hasRelatedWork W2081189719 @default.
- W2110296635 hasRelatedWork W2086232160 @default.
- W2110296635 hasRelatedWork W2089893838 @default.
- W2110296635 hasRelatedWork W2110296635 @default.
- W2110296635 hasRelatedWork W2217999767 @default.
- W2110296635 hasRelatedWork W2411486900 @default.
- W2110296635 hasRelatedWork W2415386437 @default.
- W2110296635 hasRelatedWork W2464830678 @default.
- W2110296635 hasRelatedWork W2695612728 @default.
- W2110296635 hasVolume "8" @default.
- W2110296635 isParatext "false" @default.
- W2110296635 isRetracted "false" @default.
- W2110296635 magId "2110296635" @default.
- W2110296635 workType "article" @default.