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• W2110307604 abstract "Background: The relationship between serum cholesterol and cancer incidence remains controversial.Patients and methods: We investigated the association of total serum cholesterol (TSC) with subsequent cancer incidence in a population-based cohort of 172 210 Austrian adults prospectively followed up for a median of 13.0 years. Cox regression, allowing for time-dependent effects, was used to estimate adjusted hazard ratios (HRs) with 95% confidence intervals (95% CIs) for the association of TSC with cancer.Results: We observed pronounced short-term associations of TSC and overall cancer incidence in both men and women. For malignancies diagnosed shortly (<5 months) after baseline TSC measurement, the highest TSC tertile (>235.0 mg/dl in men and >229.0 in women) compared with the lowest tertile (<194.0 mg/dl in men and <190.0 in women) was associated with a significantly lower overall cancer risk [HR = 0.58 (95% CI 0.43–0.78, Ptrend = 0.0001) in men, HR = 0.69 (95% CI 0.49–0.99, Ptrend = 0.03) in women]. However, after roughly 5 months from baseline measurement, overall cancer risk was not significantly associated with TSC. The short-term inverse association of TSC with cancer was mainly driven by malignancies of the digestive organs and lymphoid and hematopoietic tissue.Conclusion: The short-term decrease of cancer risk seen for high levels of TSC may largely capture preclinical effects of cancer on TSC." @default.
• W2110307604 created "2016-06-24" @default.
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• W2110307604 date "2009-06-01" @default.
• W2110307604 modified "2023-10-17" @default.
• W2110307604 title "Time-dependent association of total serum cholesterol and cancer incidence in a cohort of 172 210 men and women: a prospective 19-year follow-up study" @default.
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• W2110307604 doi "https://doi.org/10.1093/annonc/mdn736" @default.
• W2110307604 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2685450" @default.
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