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• W2110308923 endingPage "5572" @default.
• W2110308923 startingPage "5562" @default.
• W2110308923 abstract "Inflammatory mediators and viral products produced by human immunodeficiency virus (HIV)-infected microglia and astrocytes perturb the function and viability of adjacent uninfected neuronal and glial cells and contribute to the pathogenesis of HIV-associated neurocognitive disorders (HAND). In vivo exposure to lipopolysaccharide (LPS) activates parenchymal microglia and astrocytes and induces cytokine and chemokine production in the brain. HIV-infected individuals display increased circulating LPS levels due to microbial translocation across a compromised mucosa barrier. We hypothesized that HIV-infected microglia and astrocytes display increased sensitivity to the proinflammatory effects of LPS, and this combines with the increased levels of systemic LPS in HIV-infected individuals to contribute to the development of HAND. To examine this possibility, we determined the in vivo responsiveness of HIV-infected microglia and astrocytes to LPS using our mouse model, JR-CSF/human cyclin T1 (JR-CSF/hu-cycT1) mice, which are transgenic for both an integrated full-length infectious HIV type 1 (HIV-1) provirus derived from the primary R5-tropic clinical isolate HIV-1(JR-CSF) regulated by the endogenous HIV-1 long terminal repeat and the hu-cycT1 gene under the control of a CD4 promoter. In the current report, we demonstrated that in vivo-administered LPS more potently activated JR-CSF/hu-cycT1 mouse microglia and astrocytes and induced a significantly higher degree of monocyte chemoattractant protein production by JR-CSF/hu-cycT1 astrocytes compared to that of the in vivo LPS response of control littermate mouse microglia and astrocytes. These results indicate that HIV infection increases the sensitivity of microglia and astrocytes to inflammatory stimulation and support the use of these mice as a model to investigate various aspects of the in vivo mechanism of HIV-induced neuronal dysfunction." @default.
• W2110308923 created "2016-06-24" @default.
• W2110308923 creator A5049518177 @default.
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• W2110308923 creator A5078672361 @default.
• W2110308923 creator A5086420278 @default.
• W2110308923 creator A5089011676 @default.
• W2110308923 date "2008-06-01" @default.
• W2110308923 modified "2023-10-06" @default.
• W2110308923 title "Increased In Vivo Activation of Microglia and Astrocytes in the Brains of Mice Transgenic for an Infectious R5 Human Immunodeficiency Virus Type 1 Provirus and for CD4-Specific Expression of Human Cyclin T1 in Response to Stimulation by Lipopolysaccharides" @default.
• W2110308923 cites W1482844117 @default.
• W2110308923 cites W1595549379 @default.
• W2110308923 cites W1620558271 @default.
• W2110308923 cites W1826650183 @default.
• W2110308923 cites W1892809027 @default.
• W2110308923 cites W1909519734 @default.
• W2110308923 cites W1925136148 @default.
• W2110308923 cites W1965481178 @default.
• W2110308923 cites W1966839779 @default.
• W2110308923 cites W1974002544 @default.
• W2110308923 cites W1980542724 @default.
• W2110308923 cites W1985210427 @default.
• W2110308923 cites W1986245710 @default.
• W2110308923 cites W1988867798 @default.
• W2110308923 cites W1990773400 @default.
• W2110308923 cites W1991401739 @default.
• W2110308923 cites W1993715125 @default.
• W2110308923 cites W1995924099 @default.
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• W2110308923 cites W2000673488 @default.
• W2110308923 cites W2003575672 @default.
• W2110308923 cites W2005076304 @default.
• W2110308923 cites W2007022317 @default.
• W2110308923 cites W2010534025 @default.
• W2110308923 cites W2011850477 @default.
• W2110308923 cites W2012490203 @default.
• W2110308923 cites W2012694713 @default.
• W2110308923 cites W2015392944 @default.
• W2110308923 cites W2018876654 @default.
• W2110308923 cites W2024803597 @default.
• W2110308923 cites W2029752579 @default.
• W2110308923 cites W2036890038 @default.
• W2110308923 cites W2046091591 @default.
• W2110308923 cites W2047385013 @default.
• W2110308923 cites W2048699193 @default.
• W2110308923 cites W2051596822 @default.
• W2110308923 cites W2053176712 @default.
• W2110308923 cites W2056858031 @default.
• W2110308923 cites W2071598563 @default.
• W2110308923 cites W2074070803 @default.
• W2110308923 cites W2083829960 @default.
• W2110308923 cites W2089389165 @default.
• W2110308923 cites W2091856865 @default.
• W2110308923 cites W2092580120 @default.
• W2110308923 cites W2093530590 @default.
• W2110308923 cites W2093611886 @default.
• W2110308923 cites W2094180811 @default.
• W2110308923 cites W2101907803 @default.
• W2110308923 cites W2111838184 @default.
• W2110308923 cites W2113212678 @default.
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• W2110308923 cites W2119395157 @default.
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• W2110308923 cites W2135551147 @default.
• W2110308923 cites W2135736528 @default.
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• W2110308923 cites W2147625085 @default.
• W2110308923 cites W2147638621 @default.
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• W2110308923 cites W2163466475 @default.
• W2110308923 cites W2164663536 @default.
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• W2110308923 doi "https://doi.org/10.1128/jvi.02618-07" @default.
• W2110308923 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2395169" @default.
• W2110308923 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18353948" @default.
• W2110308923 hasPublicationYear "2008" @default.
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