FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2110315105> ?p ?o ?g. }

• W2110315105 endingPage "G1258" @default.
• W2110315105 startingPage "G1250" @default.
• W2110315105 abstract "Studies in humans and rodents suggest that colon inflammation promotes urinary bladder hypersensitivity and, conversely, that cystitis contributes to colon hypersensitivity, events referred to as cross-organ sensitization. To investigate a potential peripheral mechanism, we examined whether cystitis alters the sensitivity of pelvic nerve colorectal afferents. Male C57BL/6 mice were treated with cyclophosphamide (CYP) or saline, and the mechanosensitive properties of single afferent fibers innervating the colorectum were studied with an in vitro preparation. In addition, mechanosensitive receptive endings were exposed to an inflammatory soup (IS) to study sensitization. Urinary bladder mechanosensitive afferents were also tested. We found that baseline responses of stretch-sensitive colorectal afferents did not differ between treatment groups. Whereas IS excited a proportion of colorectal afferents CYP treatment did not alter the magnitude of this response. However, the number of stretch-sensitive fibers excited by IS was increased relative to saline-treated mice. Responses to IS were not altered by CYP treatment, but the proportion of IS-responsive fibers was increased relative to saline-treated mice. In bladder, IS application increased responses of muscular afferents to stretch, although no differences were detected between saline- and CYP-treated mice. In contrast, their chemosensitivity to IS was decreased in the CYP-treated group. Histological examination revealed no changes in colorectum and modest edema and infiltration in the urinary bladder of CYP-treated mice. In conclusion, CYP treatment increased mechanical sensitivity of colorectal muscular afferents and increased the proportion of chemosensitive colorectal afferents. These data support a peripheral contribution to cross-organ sensitization of pelvic organs." @default.
• W2110315105 created "2016-06-24" @default.
• W2110315105 creator A5009080713 @default.
• W2110315105 creator A5047846623 @default.
• W2110315105 creator A5060362286 @default.
• W2110315105 creator A5064479411 @default.
• W2110315105 creator A5064826514 @default.
• W2110315105 date "2009-12-01" @default.
• W2110315105 modified "2023-10-01" @default.
• W2110315105 title "Cystitis increases colorectal afferent sensitivity in the mouse" @default.
• W2110315105 cites W1520881302 @default.
• W2110315105 cites W1536395076 @default.
• W2110315105 cites W1580894596 @default.
• W2110315105 cites W1591520188 @default.
• W2110315105 cites W1965498307 @default.
• W2110315105 cites W1966507881 @default.
• W2110315105 cites W1969400739 @default.
• W2110315105 cites W1971263387 @default.
• W2110315105 cites W1971964695 @default.
• W2110315105 cites W1972549815 @default.
• W2110315105 cites W1973436974 @default.
• W2110315105 cites W1979826634 @default.
• W2110315105 cites W1982295725 @default.
• W2110315105 cites W1989743377 @default.
• W2110315105 cites W1993187759 @default.
• W2110315105 cites W1997987804 @default.
• W2110315105 cites W2000234445 @default.
• W2110315105 cites W2013676248 @default.
• W2110315105 cites W2015638728 @default.
• W2110315105 cites W2021033497 @default.
• W2110315105 cites W2021295767 @default.
• W2110315105 cites W2029223530 @default.
• W2110315105 cites W2035992427 @default.
• W2110315105 cites W2037369632 @default.
• W2110315105 cites W2037728798 @default.
• W2110315105 cites W2044092388 @default.
• W2110315105 cites W2044974031 @default.
• W2110315105 cites W2045510356 @default.
• W2110315105 cites W2048050019 @default.
• W2110315105 cites W2052448477 @default.
• W2110315105 cites W2054246621 @default.
• W2110315105 cites W2055890544 @default.
• W2110315105 cites W2055999473 @default.
• W2110315105 cites W2058262412 @default.
• W2110315105 cites W2064267093 @default.
• W2110315105 cites W2071541376 @default.
• W2110315105 cites W2071819583 @default.
• W2110315105 cites W2078765363 @default.
• W2110315105 cites W2079005522 @default.
• W2110315105 cites W2080067399 @default.
• W2110315105 cites W2080874483 @default.
• W2110315105 cites W2081718040 @default.
• W2110315105 cites W2085023173 @default.
• W2110315105 cites W2087082823 @default.
• W2110315105 cites W2089011195 @default.
• W2110315105 cites W2090754553 @default.
• W2110315105 cites W2092334369 @default.
• W2110315105 cites W2100459283 @default.
• W2110315105 cites W2106324362 @default.
• W2110315105 cites W2107988902 @default.
• W2110315105 cites W2112286648 @default.
• W2110315105 cites W2116764810 @default.
• W2110315105 cites W2126245788 @default.
• W2110315105 cites W2127332900 @default.
• W2110315105 cites W2130479997 @default.
• W2110315105 cites W2132926305 @default.
• W2110315105 cites W2139416059 @default.
• W2110315105 cites W2145414080 @default.
• W2110315105 cites W2154105016 @default.
• W2110315105 cites W2156953890 @default.
• W2110315105 cites W2163156031 @default.
• W2110315105 cites W2164676774 @default.
• W2110315105 cites W2321128198 @default.
• W2110315105 cites W2410317970 @default.
• W2110315105 doi "https://doi.org/10.1152/ajpgi.00329.2009" @default.
• W2110315105 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2850082" @default.
• W2110315105 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19779012" @default.
• W2110315105 hasPublicationYear "2009" @default.
• W2110315105 type Work @default.
• W2110315105 sameAs 2110315105 @default.
• W2110315105 citedByCount "34" @default.
• W2110315105 countsByYear W21103151052012 @default.
• W2110315105 countsByYear W21103151052013 @default.
• W2110315105 countsByYear W21103151052014 @default.
• W2110315105 countsByYear W21103151052015 @default.
• W2110315105 countsByYear W21103151052016 @default.
• W2110315105 countsByYear W21103151052017 @default.
• W2110315105 countsByYear W21103151052018 @default.
• W2110315105 countsByYear W21103151052020 @default.
• W2110315105 countsByYear W21103151052021 @default.
• W2110315105 countsByYear W21103151052022 @default.
• W2110315105 countsByYear W21103151052023 @default.
• W2110315105 crossrefType "journal-article" @default.
• W2110315105 hasAuthorship W2110315105A5009080713 @default.
• W2110315105 hasAuthorship W2110315105A5047846623 @default.
• W2110315105 hasAuthorship W2110315105A5060362286 @default.
• W2110315105 hasAuthorship W2110315105A5064479411 @default.
• W2110315105 hasAuthorship W2110315105A5064826514 @default.

• next