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• W2110317260 abstract "<i>Chlamydia pneumoniae</i> is an important respiratory pathogen. Recently, its presence has been demonstrated in atherosclerotic lesions. In this study, we characterized <i>C. pneumoniae</i>-mediated activation of endothelial cells and demonstrated an enhanced expression of endothelial adhesion molecules followed by subsequent rolling, adhesion, and transmigration of leukocytes (monocytes, granulocytes). These effects were blocked by mAbs against endothelial and/or leukocyte adhesion molecules (β₁ and β₂ integrins). Additionally, activation of different signal transduction pathways in <i>C. pneumoniae</i>-infected endothelial cells was shown: protein tyrosine phosphorylation, up-regulation of phosphorylated p42/p44 mitogen-activated protein kinase, and NF-κB activation/translocation occurred within 10–15 min. Increased mRNA and surface expression of E-selectin, ICAM-1, and VCAM-1 were noted within hours. Thus, <i>C. pneumoniae</i> triggers a cascade of events that could lead to endothelial activation, inflammation, and thrombosis, which in turn may result in or may promote atherosclerosis." @default.
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• W2110317260 date "2012-12-20" @default.
• W2110317260 modified "2023-10-16" @default.
• W2110317260 title "In situ simulation: detection of safety threats and teamwork training in a high risk emergency department" @default.
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• W2110317260 doi "https://doi.org/10.1136/bmjqs-2012-000942" @default.
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