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• W2110321854 endingPage "2043" @default.
• W2110321854 startingPage "2037" @default.
• W2110321854 abstract "Telomere length and function are crucial factors that determine the capacity for cell proliferation and survival, mediate cellular senescence, and play a role in malignant transformation in eukaryotic systems. The telomere length of a specific mammalian species is maintained within a given range by the action of telomerase and telomere-associated proteins. TRF1 is a telomere-associated protein that inhibits telomere elongation by its binding to telomere repeats, preventing access to telomerase. Human TRF1 interacts with tankyrase 1 and tankyrase 2 proteins, two related members of the tankyrase family shown to have poly(ADP-ribose) polymerase activity. Human tankyrase 1 is reported to ADP-ribosylate TRF1 and to down-regulate the telomeric repeat binding activity of TRF1, resulting in telomerase-dependent telomere elongation. Human tankyrase 2 is proposed to have activity similar to that of tankyrase 1, although tankyrase 2 function has been less extensively characterized. In the present study, we have assessed the in vivo function of mouse tankyrase 2 by germ line gene inactivation and show that inactivation of tankyrase 2 does not result in detectable alteration in telomere length when monitored through multiple generations of breeding. This finding suggests that either mouse tankyrases 1 and 2 have redundant functions in telomere length maintenance or that mouse tankyrase 2 differs from human tankyrase 2 in its role in telomere length maintenance. Tankyrase 2 deficiency did result in a significant decrease in body weight sustained through at least the first year of life, most marked in male mice, suggesting that tankyrase 2 functions in potentially telomerase-independent pathways to affect overall development and/or metabolism." @default.
• W2110321854 created "2016-06-24" @default.
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• W2110321854 date "2006-03-01" @default.
• W2110321854 modified "2023-10-14" @default.
• W2110321854 title "Generation and Characterization of Telomere Length Maintenance in Tankyrase 2-Deficient Mice" @default.
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• W2110321854 doi "https://doi.org/10.1128/mcb.26.6.2037-2043.2006" @default.
• W2110321854 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1430286" @default.
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