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• W2110324729 endingPage "1991" @default.
• W2110324729 startingPage "1983" @default.
• W2110324729 abstract "Short interspersed elements (SINEs) make up a significant fraction of total DNA in mammalian genomes, providing a rich substrate for chromosomal rearrangements by SINE-SINE recombinations. Proliferation of mammalian SINEs is mediated primarily by long interspersed element 1 (L1) non-long terminal repeat retrotransposons that preferentially integrate at DNA sequence targets with an average length of approximately 15 bp and containing conserved endonucleolytic nicking signals at both ends. We report that sequence variations in the first of the two nicking signals, represented by a 5'-TT-AAAA consensus sequence, affect the position of the second signal thus leading to target site duplications (TSDs) of different lengths. The length distribution of TSDs appears to be affected also by L1-encoded enzyme variants because targets with the same 5' nicking site can be of different average lengths in different mammalian species. Taking this into account, we reanalyzed the second nicking site and found that it is larger and includes more conserved sites than previously appreciated, with a consensus of 5'-ANTNTN-AA. We also studied potential involvement of the nicking sites in stimulating recombinations between SINEs. We determined that SINEs retaining TSDs with perfect 5'-TT-AAAA nicking sites appear to be lost relatively rapidly from the human and rat genomes and less rapidly from dog. We speculate that the introduction of DNA breaks induced by recurring endonucleolytic attacks at these sites, combined with the ubiquitousness of SINEs, may significantly promote recombination between repetitive elements, leading to the observed losses. At the same time, new L1 subfamilies may be selected for incompatibility with preexisting targets. This provides a possible driving force for the continual emergence of new L1 subfamilies which, in turn, may affect selection of L1-dependent SINE subfamilies." @default.
• W2110324729 created "2016-06-24" @default.
• W2110324729 creator A5015367801 @default.
• W2110324729 creator A5046140078 @default.
• W2110324729 creator A5051381422 @default.
• W2110324729 date "2005-06-08" @default.
• W2110324729 modified "2023-09-26" @default.
• W2110324729 title "Evolutionary Diversity and Potential Recombinogenic Role of Integration Targets of Non-LTR Retrotransposons" @default.
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• W2110324729 doi "https://doi.org/10.1093/molbev/msi188" @default.
• W2110324729 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1400617" @default.
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