Matches in SemOpenAlex for { <https://semopenalex.org/work/W2110337318> ?p ?o ?g. }
- W2110337318 endingPage "739" @default.
- W2110337318 startingPage "727" @default.
- W2110337318 abstract "Centrioles are self-reproducing organelles that form the core structure of centrosomes or microtubule-organizing centers (MTOCs). However, whether duplication and MTOC organization reflect innate activities of centrioles or activities acquired conditionally is unclear. In this paper, we show that newly formed full-length centrioles had no inherent capacity to duplicate or to organize pericentriolar material (PCM) but acquired both after mitosis through a Plk1-dependent modification that occurred in early mitosis. Modified centrioles initiated PCM recruitment in G1 and segregated equally in mitosis through association with spindle poles. Conversely, unmodified centrioles segregated randomly unless passively tethered to modified centrioles. Strikingly, duplication occurred only in centrioles that were both modified and disengaged, whereas unmodified centrioles, engaged or not, were “infertile,” indicating that engagement specifically blocks modified centrioles from reduplication. These two requirements, centriole modification and disengagement, fully exclude unlimited duplication in one cell cycle. We thus uncovered a Plk1-dependent mechanism whereby duplication and segregation are coupled to maintain centriole homeostasis." @default.
- W2110337318 created "2016-06-24" @default.
- W2110337318 creator A5002979482 @default.
- W2110337318 creator A5015641908 @default.
- W2110337318 creator A5052968100 @default.
- W2110337318 creator A5077227628 @default.
- W2110337318 date "2011-05-16" @default.
- W2110337318 modified "2023-09-30" @default.
- W2110337318 title "The conversion of centrioles to centrosomes: essential coupling of duplication with segregation" @default.
- W2110337318 cites W1518355667 @default.
- W2110337318 cites W1963981052 @default.
- W2110337318 cites W1968484697 @default.
- W2110337318 cites W1977721021 @default.
- W2110337318 cites W1985646870 @default.
- W2110337318 cites W1988573682 @default.
- W2110337318 cites W1988941690 @default.
- W2110337318 cites W1995078993 @default.
- W2110337318 cites W1998406437 @default.
- W2110337318 cites W2001510870 @default.
- W2110337318 cites W2001947684 @default.
- W2110337318 cites W2004548769 @default.
- W2110337318 cites W2009271990 @default.
- W2110337318 cites W2012950009 @default.
- W2110337318 cites W2014871864 @default.
- W2110337318 cites W2016550539 @default.
- W2110337318 cites W2019013949 @default.
- W2110337318 cites W2028878012 @default.
- W2110337318 cites W2030645367 @default.
- W2110337318 cites W2030690279 @default.
- W2110337318 cites W2031949048 @default.
- W2110337318 cites W2035895891 @default.
- W2110337318 cites W2036982993 @default.
- W2110337318 cites W2048191614 @default.
- W2110337318 cites W2049477499 @default.
- W2110337318 cites W2049526129 @default.
- W2110337318 cites W2054141330 @default.
- W2110337318 cites W2054146568 @default.
- W2110337318 cites W2055090638 @default.
- W2110337318 cites W2060387325 @default.
- W2110337318 cites W2061668593 @default.
- W2110337318 cites W2071156666 @default.
- W2110337318 cites W2072895299 @default.
- W2110337318 cites W2078073456 @default.
- W2110337318 cites W2082135457 @default.
- W2110337318 cites W2082968313 @default.
- W2110337318 cites W2090532223 @default.
- W2110337318 cites W2095750516 @default.
- W2110337318 cites W2102532917 @default.
- W2110337318 cites W2103166084 @default.
- W2110337318 cites W2125248031 @default.
- W2110337318 cites W2126655590 @default.
- W2110337318 cites W2127884633 @default.
- W2110337318 cites W2128126810 @default.
- W2110337318 cites W2128199009 @default.
- W2110337318 cites W2134393105 @default.
- W2110337318 cites W2142351641 @default.
- W2110337318 cites W2151602082 @default.
- W2110337318 cites W2153441154 @default.
- W2110337318 cites W2157443774 @default.
- W2110337318 cites W2159243681 @default.
- W2110337318 cites W2162563526 @default.
- W2110337318 cites W2165703806 @default.
- W2110337318 cites W2166882183 @default.
- W2110337318 cites W2167756140 @default.
- W2110337318 cites W4211128376 @default.
- W2110337318 cites W4253916311 @default.
- W2110337318 cites W63353829 @default.
- W2110337318 doi "https://doi.org/10.1083/jcb.201101109" @default.
- W2110337318 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3166877" @default.
- W2110337318 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21576395" @default.
- W2110337318 hasPublicationYear "2011" @default.
- W2110337318 type Work @default.
- W2110337318 sameAs 2110337318 @default.
- W2110337318 citedByCount "146" @default.
- W2110337318 countsByYear W21103373182012 @default.
- W2110337318 countsByYear W21103373182013 @default.
- W2110337318 countsByYear W21103373182014 @default.
- W2110337318 countsByYear W21103373182015 @default.
- W2110337318 countsByYear W21103373182016 @default.
- W2110337318 countsByYear W21103373182017 @default.
- W2110337318 countsByYear W21103373182018 @default.
- W2110337318 countsByYear W21103373182019 @default.
- W2110337318 countsByYear W21103373182020 @default.
- W2110337318 countsByYear W21103373182021 @default.
- W2110337318 countsByYear W21103373182022 @default.
- W2110337318 countsByYear W21103373182023 @default.
- W2110337318 crossrefType "journal-article" @default.
- W2110337318 hasAuthorship W2110337318A5002979482 @default.
- W2110337318 hasAuthorship W2110337318A5015641908 @default.
- W2110337318 hasAuthorship W2110337318A5052968100 @default.
- W2110337318 hasAuthorship W2110337318A5077227628 @default.
- W2110337318 hasBestOaLocation W21103373181 @default.
- W2110337318 hasConcept C10447061 @default.
- W2110337318 hasConcept C104672736 @default.
- W2110337318 hasConcept C1491633281 @default.
- W2110337318 hasConcept C29537977 @default.
- W2110337318 hasConcept C44064316 @default.
- W2110337318 hasConcept C48342290 @default.