FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2110338639> ?p ?o ?g. }

• W2110338639 endingPage "467" @default.
• W2110338639 startingPage "457" @default.
• W2110338639 abstract "Immunization of C57BL/6 (B6) mice with FBL, a Friend murine leukemia virus (F-MuLV), induces both tumor-specific cytolytic CD8+ (CTL) and lymphokine-producing CD4+ Th that are effective in adoptive therapy of B6 mice bearing disseminated FBL leukemia. The current study evaluated the F-MuLV antigenic determinants expressed on FBL that are recognized by FBL-reactive CD8+ and CD4+ T cells. To identify the specificity of the FBL-reactive CD8+ CTL, Fisher rat embryo fibroblast (FRE) cells transfected with plasmids encoding F-MuLV gag or envelope (env) gene products plus the class I-restricting element Db were utilized. FBL-reactive CTL recognized FRE target cells transfected with the F-MuLV gag-encoded gene products, but failed to recognize targets expressing F-MuLV env. Attempts to generate env-specific CD8+ CTL by immunization with a recombinant vaccinia virus containing an inserted F-MuLV env gene were unsuccessful, despite the generation of a cytolytic response to vaccinia epitopes, implying that B6 mice fail to generate CD8+ CTL to env determinants. By contrast, CD4+ Th clones recognized FRE target cells transfected with env and not gag genes, and immunization with the recombinant vaccinia virus induced an env-specific CD4+ T cell response. These data show that in a Friend retrovirus-induced tumor model in which tumor rejection can be mediated by either CTL or Th, antigens derived from discrete retroviral proteins are predominantly responsible for activation of each T cell subset." @default.
• W2110338639 created "2016-06-24" @default.
• W2110338639 creator A5006262981 @default.
• W2110338639 creator A5022298525 @default.
• W2110338639 creator A5030463228 @default.
• W2110338639 creator A5038003907 @default.
• W2110338639 creator A5059782726 @default.
• W2110338639 creator A5064774655 @default.
• W2110338639 date "1989-02-01" @default.
• W2110338639 modified "2023-10-16" @default.
• W2110338639 title "FBL-reactive CD8+ cytotoxic and CD4+ helper T lymphocytes recognize distinct Friend murine leukemia virus-encoded antigens." @default.
• W2110338639 cites W1495708961 @default.
• W2110338639 cites W1524958846 @default.
• W2110338639 cites W1526198035 @default.
• W2110338639 cites W1527836292 @default.
• W2110338639 cites W1553066532 @default.
• W2110338639 cites W1570350778 @default.
• W2110338639 cites W1599181382 @default.
• W2110338639 cites W1602008817 @default.
• W2110338639 cites W1602388837 @default.
• W2110338639 cites W1632144192 @default.
• W2110338639 cites W1647694034 @default.
• W2110338639 cites W1845406753 @default.
• W2110338639 cites W1857659489 @default.
• W2110338639 cites W1967856579 @default.
• W2110338639 cites W1976158962 @default.
• W2110338639 cites W1990137584 @default.
• W2110338639 cites W2006597943 @default.
• W2110338639 cites W2010936770 @default.
• W2110338639 cites W2035470798 @default.
• W2110338639 cites W2036667563 @default.
• W2110338639 cites W2056346648 @default.
• W2110338639 cites W2064508262 @default.
• W2110338639 cites W2070316348 @default.
• W2110338639 cites W2074360298 @default.
• W2110338639 cites W2075928272 @default.
• W2110338639 cites W2115241901 @default.
• W2110338639 cites W2115283797 @default.
• W2110338639 cites W2116236834 @default.
• W2110338639 cites W2120931274 @default.
• W2110338639 cites W2125745098 @default.
• W2110338639 cites W2127425177 @default.
• W2110338639 cites W2151416944 @default.
• W2110338639 cites W2155964088 @default.
• W2110338639 cites W2162336526 @default.
• W2110338639 cites W2162556869 @default.
• W2110338639 cites W2169241904 @default.
• W2110338639 cites W2315326052 @default.
• W2110338639 cites W2436936271 @default.
• W2110338639 cites W2585599833 @default.
• W2110338639 cites W2615950062 @default.
• W2110338639 cites W273915685 @default.
• W2110338639 doi "https://doi.org/10.1084/jem.169.2.457" @default.
• W2110338639 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2189204" @default.
• W2110338639 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2562982" @default.
• W2110338639 hasPublicationYear "1989" @default.
• W2110338639 type Work @default.
• W2110338639 sameAs 2110338639 @default.
• W2110338639 citedByCount "72" @default.
• W2110338639 countsByYear W21103386392013 @default.
• W2110338639 countsByYear W21103386392014 @default.
• W2110338639 countsByYear W21103386392016 @default.
• W2110338639 countsByYear W21103386392018 @default.
• W2110338639 countsByYear W21103386392021 @default.
• W2110338639 countsByYear W21103386392023 @default.
• W2110338639 crossrefType "journal-article" @default.
• W2110338639 hasAuthorship W2110338639A5006262981 @default.
• W2110338639 hasAuthorship W2110338639A5022298525 @default.
• W2110338639 hasAuthorship W2110338639A5030463228 @default.
• W2110338639 hasAuthorship W2110338639A5038003907 @default.
• W2110338639 hasAuthorship W2110338639A5059782726 @default.
• W2110338639 hasAuthorship W2110338639A5064774655 @default.
• W2110338639 hasBestOaLocation W21103386391 @default.
• W2110338639 hasConcept C104317684 @default.
• W2110338639 hasConcept C147483822 @default.
• W2110338639 hasConcept C147969180 @default.
• W2110338639 hasConcept C153911025 @default.
• W2110338639 hasConcept C154317977 @default.
• W2110338639 hasConcept C159047783 @default.
• W2110338639 hasConcept C167672396 @default.
• W2110338639 hasConcept C195616568 @default.
• W2110338639 hasConcept C202751555 @default.
• W2110338639 hasConcept C203014093 @default.
• W2110338639 hasConcept C2522874641 @default.
• W2110338639 hasConcept C2779562191 @default.
• W2110338639 hasConcept C2779682186 @default.
• W2110338639 hasConcept C2781356689 @default.
• W2110338639 hasConcept C40767141 @default.
• W2110338639 hasConcept C54355233 @default.
• W2110338639 hasConcept C86803240 @default.
• W2110338639 hasConceptScore W2110338639C104317684 @default.
• W2110338639 hasConceptScore W2110338639C147483822 @default.
• W2110338639 hasConceptScore W2110338639C147969180 @default.
• W2110338639 hasConceptScore W2110338639C153911025 @default.
• W2110338639 hasConceptScore W2110338639C154317977 @default.
• W2110338639 hasConceptScore W2110338639C159047783 @default.
• W2110338639 hasConceptScore W2110338639C167672396 @default.
• W2110338639 hasConceptScore W2110338639C195616568 @default.

• next