FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2110339984> ?p ?o ?g. }

• W2110339984 endingPage "9" @default.
• W2110339984 startingPage "561" @default.
• W2110339984 abstract "The small total number of hematopoietic progenitor cells (HPC) in cord blood limited its use in adult recipients. Since the hematopoiesis might be controlled by both positive and negative factors, the finding of negative cellular components and thereafter depletion of them would be of importance for further expansion of HPC from cord blood in vitro. The role of natural killer cells (NK cells) in hematopoiesis remains unclear and needs to be elucidated.Cord blood mononuclear cells were co-cultured in a liquid culture system containing the hematopoietic cytokines interleukin (IL)-1, IL-3, IL-6, stem cell factor (SCF), granulocyte-monocyte colony-stimulating factor (GM-CSF) and G-CSF for a total of 20 days with or without depletion of NK cells.The percentage of CD34+ cells was significantly higher in the NK-cell-depleted group at each time point (day 5, day 10, day 15, day 20). This finding was further confirmed by examination of functional HPC including CFU-GM and CFU-GEMM. The intracellular interferon (IFN)-gamma and tumor necrosis factor (TNF)-alpha content of CD56+ NK cells increased more than 10-fold after incubation with hematopoietic cytokines (day 4, day 8). Neutralization of IFNgamma or TNFalpha, present in liquid culture, also significantly increased CFU-GM formation and CD34+ cell content.The results indicate that depletion of NK cells may be beneficial in producing hematopoietic progenitor cells from cord blood in ex vivo expansion systems. The effect of NK-cell depletion on ex vivo expansion of hematopoietic stem cells should be further assessed by a repopulating cell assay in NOD/SCID mice." @default.
• W2110339984 created "2016-06-24" @default.
• W2110339984 creator A5012198733 @default.
• W2110339984 creator A5021628816 @default.
• W2110339984 creator A5041353057 @default.
• W2110339984 creator A5083130438 @default.
• W2110339984 date "2003-05-01" @default.
• W2110339984 modified "2023-09-26" @default.
• W2110339984 title "The effects of natural killer-cell depletion on ex vivo expansion of hematopoietic progenitor cells from umbilical cord blood." @default.
• W2110339984 cites W111336857 @default.
• W2110339984 cites W1499537359 @default.
• W2110339984 cites W1499740654 @default.
• W2110339984 cites W1504115723 @default.
• W2110339984 cites W1526323145 @default.
• W2110339984 cites W1836124358 @default.
• W2110339984 cites W1976430696 @default.
• W2110339984 cites W20043667 @default.
• W2110339984 cites W2007552143 @default.
• W2110339984 cites W2009658831 @default.
• W2110339984 cites W2010180443 @default.
• W2110339984 cites W2013301732 @default.
• W2110339984 cites W2035703230 @default.
• W2110339984 cites W2040291293 @default.
• W2110339984 cites W2047372273 @default.
• W2110339984 cites W2054031422 @default.
• W2110339984 cites W2069078768 @default.
• W2110339984 cites W2073328751 @default.
• W2110339984 cites W2079612867 @default.
• W2110339984 cites W2085516849 @default.
• W2110339984 cites W2087440289 @default.
• W2110339984 cites W2091153543 @default.
• W2110339984 cites W2091603211 @default.
• W2110339984 cites W2092301381 @default.
• W2110339984 cites W2105929705 @default.
• W2110339984 cites W2113403004 @default.
• W2110339984 cites W2115833446 @default.
• W2110339984 cites W2123421118 @default.
• W2110339984 cites W2129321368 @default.
• W2110339984 cites W2140914490 @default.
• W2110339984 cites W2155847182 @default.
• W2110339984 cites W2159310677 @default.
• W2110339984 cites W2161290044 @default.
• W2110339984 cites W2170923796 @default.
• W2110339984 cites W224584583 @default.
• W2110339984 cites W2272909078 @default.
• W2110339984 cites W2279391286 @default.
• W2110339984 cites W2290893624 @default.
• W2110339984 cites W2330713242 @default.
• W2110339984 cites W2333162405 @default.
• W2110339984 cites W2395517345 @default.
• W2110339984 cites W2397969091 @default.
• W2110339984 cites W2443220535 @default.
• W2110339984 cites W261120209 @default.
• W2110339984 cites W3142186509 @default.
• W2110339984 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12745276" @default.
• W2110339984 hasPublicationYear "2003" @default.
• W2110339984 type Work @default.
• W2110339984 sameAs 2110339984 @default.
• W2110339984 citedByCount "0" @default.
• W2110339984 crossrefType "journal-article" @default.
• W2110339984 hasAuthorship W2110339984A5012198733 @default.
• W2110339984 hasAuthorship W2110339984A5021628816 @default.
• W2110339984 hasAuthorship W2110339984A5041353057 @default.
• W2110339984 hasAuthorship W2110339984A5083130438 @default.
• W2110339984 hasConcept C10205521 @default.
• W2110339984 hasConcept C109159458 @default.
• W2110339984 hasConcept C137061746 @default.
• W2110339984 hasConcept C201750760 @default.
• W2110339984 hasConcept C2022786 @default.
• W2110339984 hasConcept C202751555 @default.
• W2110339984 hasConcept C203014093 @default.
• W2110339984 hasConcept C26291073 @default.
• W2110339984 hasConcept C2780914630 @default.
• W2110339984 hasConcept C2781184567 @default.
• W2110339984 hasConcept C28328180 @default.
• W2110339984 hasConcept C55493867 @default.
• W2110339984 hasConcept C86803240 @default.
• W2110339984 hasConcept C95444343 @default.
• W2110339984 hasConceptScore W2110339984C10205521 @default.
• W2110339984 hasConceptScore W2110339984C109159458 @default.
• W2110339984 hasConceptScore W2110339984C137061746 @default.
• W2110339984 hasConceptScore W2110339984C201750760 @default.
• W2110339984 hasConceptScore W2110339984C2022786 @default.
• W2110339984 hasConceptScore W2110339984C202751555 @default.
• W2110339984 hasConceptScore W2110339984C203014093 @default.
• W2110339984 hasConceptScore W2110339984C26291073 @default.
• W2110339984 hasConceptScore W2110339984C2780914630 @default.
• W2110339984 hasConceptScore W2110339984C2781184567 @default.
• W2110339984 hasConceptScore W2110339984C28328180 @default.
• W2110339984 hasConceptScore W2110339984C55493867 @default.
• W2110339984 hasConceptScore W2110339984C86803240 @default.
• W2110339984 hasConceptScore W2110339984C95444343 @default.
• W2110339984 hasIssue "5" @default.
• W2110339984 hasLocation W21103399841 @default.
• W2110339984 hasOpenAccess W2110339984 @default.
• W2110339984 hasPrimaryLocation W21103399841 @default.
• W2110339984 hasRelatedWork W1994686104 @default.
• W2110339984 hasRelatedWork W2012105735 @default.

• next