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• W2110341767 startingPage "172" @default.
• W2110341767 abstract "In Caenorhabditis elegans, lack of the conserved germline RNA helicase CGH-1 causes infertility and excessive levels of physiological germline apoptosis, a process that normally claims about half of all developing oocytes. In yeast the CGH-1 ortholog is a key component of degradative “processing (P) bodies,” which may share some properties with germline protein-RNA complexes such as P granules. During oogenesis CGH-1 associates with P granules, but also accumulates to high levels in additional cytoplasmic particles. Here we show that appropriate levels and localization of CGH-1 depends on some P granule components and on mechanisms that establish meiotic development. At the same time, germ cell death is not increased by various abnormalities in P granules or meiosis. We conclude that in developing oocytes CGH-1 particles accumulate specifically in response to meiotic development and have distinct functions from P granules, and may be dynamic protein-mRNA structures. genesis 42:172–180, 2005. © 2005 Wiley-Liss, Inc." @default.
• W2110341767 created "2016-06-24" @default.
• W2110341767 creator A5011844837 @default.
• W2110341767 creator A5088001169 @default.
• W2110341767 date "2005-01-01" @default.
• W2110341767 modified "2023-10-17" @default.
• W2110341767 title "Requirement for P granules and meiosis for accumulation of the germline RNA helicase CGH-1" @default.
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• W2110341767 doi "https://doi.org/10.1002/gene.20136" @default.
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