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- W2110341920 endingPage "2086" @default.
- W2110341920 startingPage "2072" @default.
- W2110341920 abstract "The mechanisms that control cell proliferation and cell differentiation during morphogenesis of the endochondral skeleton of vertebrates are poorly understood. Indian hedgehog (Ihh) signaling from prehypertrophic chondrocytes has been implicated in the control of chondrocyte maturation by way of feedback control of a second secreted factor parathyroid hormone-related peptide (PTHrP) at the articular surfaces. Analysis of an Ihh null mutant suggests a more extensive role for Ihh in skeletal development. Mutants display markedly reduced chondrocyte proliferation, maturation of chondrocytes at inappropriate position, and a failure of osteoblast development in endochondral bones. Together, the results suggest a model in which Ihh coordinates diverse aspects of skeletal morphogenesis through PTHrP-dependent and independent processes." @default.
- W2110341920 created "2016-06-24" @default.
- W2110341920 creator A5003394161 @default.
- W2110341920 creator A5005574733 @default.
- W2110341920 creator A5008851603 @default.
- W2110341920 date "1999-08-15" @default.
- W2110341920 modified "2023-10-09" @default.
- W2110341920 title "Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation" @default.
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- W2110341920 doi "https://doi.org/10.1101/gad.13.16.2072" @default.
- W2110341920 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/316949" @default.
- W2110341920 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10465785" @default.
- W2110341920 hasPublicationYear "1999" @default.
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