Matches in SemOpenAlex for { <https://semopenalex.org/work/W2110342205> ?p ?o ?g. }
- W2110342205 endingPage "21" @default.
- W2110342205 startingPage "15" @default.
- W2110342205 abstract "A vast amount of data shows that angiogenesis has a pivotal role in tumor growth, progression, invasiveness and metastasis. This is a complex process involving essential signaling pathways such as vascular endothelial growth factor (VEGF) and Notch in vasculature, as well as additional players such as bone marrow-derived endothelial progenitor cells. Primary tumor cells, stromal cells and cancer stem cells strongly influence vessel growth in tumors. Better understanding of the role of the different pathways and the crosstalk between different cells during tumor angiogenesis are crucial factors for developing more effective anticancer therapies. Targeting angiogenic factors from the VEGF family has become an effective strategy to inhibit tumor growth and so far the most successful results are seen in metastatic colorectal cancer (CRC), renal cell carcinoma (RCC) and non-small cell lung cancer (NSCLL). Despite the initial enthusiasm, the angiogenesis inhibitors showed only moderate survival benefit as monotherapy, along with a high cost and many side effects. Obviously, other important pathways may affect the angiogenic switch, among them Notch signaling pathway attracted a large interest because its ubiquitous role in carcinogenesis and angiogenesis. Herein we present the basics for VEGF and Notch signaling pathways and current advances of targeting them in antiangiogenic, antitumor therapy." @default.
- W2110342205 created "2016-06-24" @default.
- W2110342205 creator A5060572948 @default.
- W2110342205 creator A5062544738 @default.
- W2110342205 creator A5072083260 @default.
- W2110342205 date "2014-03-25" @default.
- W2110342205 modified "2023-10-18" @default.
- W2110342205 title "Angiogenesis in cancer - general pathways and their therapeutic implications." @default.
- W2110342205 cites W1577788507 @default.
- W2110342205 cites W1783580437 @default.
- W2110342205 cites W1968306881 @default.
- W2110342205 cites W1968504912 @default.
- W2110342205 cites W1969328947 @default.
- W2110342205 cites W1978139448 @default.
- W2110342205 cites W1985712533 @default.
- W2110342205 cites W1997971145 @default.
- W2110342205 cites W2000292756 @default.
- W2110342205 cites W2003650290 @default.
- W2110342205 cites W2004419844 @default.
- W2110342205 cites W2010300658 @default.
- W2110342205 cites W2013312964 @default.
- W2110342205 cites W2016093753 @default.
- W2110342205 cites W2018348203 @default.
- W2110342205 cites W2031191981 @default.
- W2110342205 cites W2034458870 @default.
- W2110342205 cites W2040827891 @default.
- W2110342205 cites W2051319925 @default.
- W2110342205 cites W2054001958 @default.
- W2110342205 cites W2062711358 @default.
- W2110342205 cites W2069937695 @default.
- W2110342205 cites W2070369200 @default.
- W2110342205 cites W2073890207 @default.
- W2110342205 cites W2076274098 @default.
- W2110342205 cites W2080637883 @default.
- W2110342205 cites W2085682228 @default.
- W2110342205 cites W2094935740 @default.
- W2110342205 cites W2105666596 @default.
- W2110342205 cites W2111818745 @default.
- W2110342205 cites W2117748018 @default.
- W2110342205 cites W2129331774 @default.
- W2110342205 cites W2138576559 @default.
- W2110342205 cites W2141046053 @default.
- W2110342205 cites W2141659416 @default.
- W2110342205 cites W2145835533 @default.
- W2110342205 cites W2147834058 @default.
- W2110342205 cites W2148242912 @default.
- W2110342205 cites W2148601578 @default.
- W2110342205 cites W2149456801 @default.
- W2110342205 cites W2150455500 @default.
- W2110342205 cites W2159842699 @default.
- W2110342205 cites W2165741055 @default.
- W2110342205 cites W2168833693 @default.
- W2110342205 cites W2188739445 @default.
- W2110342205 cites W2222593999 @default.
- W2110342205 cites W2244100803 @default.
- W2110342205 cites W2274323124 @default.
- W2110342205 cites W2278944712 @default.
- W2110342205 cites W2305352133 @default.
- W2110342205 cites W2327522594 @default.
- W2110342205 cites W2332800771 @default.
- W2110342205 cites W2529558146 @default.
- W2110342205 cites W67217088 @default.
- W2110342205 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24659637" @default.
- W2110342205 hasPublicationYear "2014" @default.
- W2110342205 type Work @default.
- W2110342205 sameAs 2110342205 @default.
- W2110342205 citedByCount "40" @default.
- W2110342205 countsByYear W21103422052014 @default.
- W2110342205 countsByYear W21103422052015 @default.
- W2110342205 countsByYear W21103422052016 @default.
- W2110342205 countsByYear W21103422052017 @default.
- W2110342205 countsByYear W21103422052018 @default.
- W2110342205 countsByYear W21103422052019 @default.
- W2110342205 countsByYear W21103422052020 @default.
- W2110342205 countsByYear W21103422052022 @default.
- W2110342205 countsByYear W21103422052023 @default.
- W2110342205 crossrefType "journal-article" @default.
- W2110342205 hasAuthorship W2110342205A5060572948 @default.
- W2110342205 hasAuthorship W2110342205A5062544738 @default.
- W2110342205 hasAuthorship W2110342205A5072083260 @default.
- W2110342205 hasConcept C120665830 @default.
- W2110342205 hasConcept C121332964 @default.
- W2110342205 hasConcept C121608353 @default.
- W2110342205 hasConcept C126322002 @default.
- W2110342205 hasConcept C161879069 @default.
- W2110342205 hasConcept C167734588 @default.
- W2110342205 hasConcept C16930146 @default.
- W2110342205 hasConcept C169822122 @default.
- W2110342205 hasConcept C201750760 @default.
- W2110342205 hasConcept C2777025900 @default.
- W2110342205 hasConcept C2779013556 @default.
- W2110342205 hasConcept C2780394083 @default.
- W2110342205 hasConcept C28328180 @default.
- W2110342205 hasConcept C502942594 @default.
- W2110342205 hasConcept C555283112 @default.
- W2110342205 hasConcept C62478195 @default.
- W2110342205 hasConcept C71924100 @default.
- W2110342205 hasConcept C86803240 @default.