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• W2110342877 abstract "<h3>Objectives</h3> The present study assesses the relationship between contents of GD1 (glycerol dehydratase)-positive <i>Lactobacillus</i>, presence of <i>Lactobacillus</i> and the inflammatory response measured in host lung tissue in mild to moderate chronic obstructive pulmonary disease (COPD). We hypothesise that there will be a loss of GD1 producing <i>Lactobacillus</i> with increasing severity of COPD and that GD1 has anti-inflammatory properties. <h3>Setting</h3> Secondary care, 1 participating centre in Vancouver, British Columbia, Canada. <h3>Participants</h3> 74 individuals who donated non-cancerous portions of their lungs or lobes removed as treatment for lung cancer (normal lung function controls (n=28), persons with mild (GOLD 1) (n=21) and moderate (GOLD 2) COPD (n=25)). <h3>Outcome measures</h3> Primary outcome measure was GD1 positivity within each group and whether or not this impacted quantitative histological measures of lung inflammation. Secondary outcome measures included <i>Lactobacillus</i> presence and quantification, and quantitative histological measurements of inflammation and remodelling in early COPD. <h3>Results</h3> Total bacterial count (p>0.05) and prevalence of <i>Lactobacillus</i> (p>0.05) did not differ between groups. However, the GD1 gene was detected more frequently in the controls (14%) than in either mild (5%) or moderate (0%) COPD (p<0.05) samples. Macrophage and neutrophil volume fractions (0.012±0.005 (mean±SD) vs 0.026±0.017 and 0.005±0.002 vs 0.015±0.014, respectively) in peripheral lung tissue were reduced in samples positive for the GD1 gene (p<0.0035). <h3>Conclusions</h3> A reduction in GD1 positivity is associated with an increased tissue immune inflammatory response in early stage COPD. There is potential for <i>Lactobacillus</i> to be used as a possible therapeutic, however, validation of these results need to be completed before an anti-inflammatory role of <i>Lactobacillus</i> in COPD can be confirmed." @default.
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• W2110342877 date "2015-02-04" @default.
• W2110342877 modified "2023-09-27" @default.
• W2110342877 title "Loss of GD1-positive Lactobacillus correlates with inflammation in human lungs with COPD" @default.
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• W2110342877 doi "https://doi.org/10.1136/bmjopen-2014-006677" @default.
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