FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2110343366> ?p ?o ?g. }

• W2110343366 endingPage "906" @default.
• W2110343366 startingPage "896" @default.
• W2110343366 abstract "Monocytes and kidney-resident macrophages are considered to be involved in the pathogenesis of renal ischemia-reperfusion injury (IRI). Several subsets of monocytes and macrophages are localized in the injured tissue, but the pathologic roles of these cells are not fully understood. Here, we show that CD169+ monocytes and macrophages have a critical role in preventing excessive inflammation in IRI by downregulating intercellular adhesion molecule-1 (ICAM-1) expression on vascular endothelial cells. Mice depleted of CD169+ cells showed enhanced endothelial ICAM-1 expression and developed irreversible renal damage associated with infiltration of a large number of neutrophils. The perivascular localization of CD169+ monocytes and macrophages indicated direct interaction with blood vessels, and coculture experiments showed that the direct interaction of CD169+ cell-depleted peripheral blood leukocytes augments the expression levels of ICAM-1 on endothelial cells. Notably, the transfer of Ly6Clo monocytes into CD169+ cell-depleted mice rescued the mice from lethal renal injury and normalized renal ICAM-1 expression levels, indicating that the Ly6Clo subset of CD169+ monocytes has a major role in the regulation of inflammation. Our findings highlight the previously unknown role of CD169+ monocytes and macrophages in the maintenance of vascular homeostasis and provide new approaches to the treatment of renal IRI." @default.
• W2110343366 created "2016-06-24" @default.
• W2110343366 creator A5013589171 @default.
• W2110343366 creator A5020537311 @default.
• W2110343366 creator A5024728176 @default.
• W2110343366 creator A5025609918 @default.
• W2110343366 creator A5047849518 @default.
• W2110343366 creator A5054900805 @default.
• W2110343366 creator A5063904443 @default.
• W2110343366 creator A5070494006 @default.
• W2110343366 creator A5078591745 @default.
• W2110343366 creator A5078790639 @default.
• W2110343366 creator A5088787939 @default.
• W2110343366 date "2015-04-01" @default.
• W2110343366 modified "2023-10-18" @default.
• W2110343366 title "Vascular-Resident CD169-Positive Monocytes and Macrophages Control Neutrophil Accumulation in the Kidney with Ischemia-Reperfusion Injury" @default.
• W2110343366 cites W1526209767 @default.
• W2110343366 cites W1797447807 @default.
• W2110343366 cites W1965693998 @default.
• W2110343366 cites W1966454841 @default.
• W2110343366 cites W1969119554 @default.
• W2110343366 cites W1971799714 @default.
• W2110343366 cites W1973433801 @default.
• W2110343366 cites W1975729112 @default.
• W2110343366 cites W1977012724 @default.
• W2110343366 cites W1979292513 @default.
• W2110343366 cites W1984996259 @default.
• W2110343366 cites W1985502949 @default.
• W2110343366 cites W2010876644 @default.
• W2110343366 cites W2024826635 @default.
• W2110343366 cites W2026578487 @default.
• W2110343366 cites W2044274736 @default.
• W2110343366 cites W2053402030 @default.
• W2110343366 cites W2053583666 @default.
• W2110343366 cites W2066005598 @default.
• W2110343366 cites W2072805330 @default.
• W2110343366 cites W2080844075 @default.
• W2110343366 cites W2081500137 @default.
• W2110343366 cites W2095400574 @default.
• W2110343366 cites W2109627278 @default.
• W2110343366 cites W2110720586 @default.
• W2110343366 cites W2110899107 @default.
• W2110343366 cites W2113702305 @default.
• W2110343366 cites W2118097954 @default.
• W2110343366 cites W2125600524 @default.
• W2110343366 cites W2127802406 @default.
• W2110343366 cites W2129663763 @default.
• W2110343366 cites W2130059324 @default.
• W2110343366 cites W2135647797 @default.
• W2110343366 cites W2135703618 @default.
• W2110343366 cites W2141293982 @default.
• W2110343366 cites W2141781896 @default.
• W2110343366 cites W2145375514 @default.
• W2110343366 cites W2148898943 @default.
• W2110343366 cites W2150897631 @default.
• W2110343366 cites W2151362823 @default.
• W2110343366 cites W2153406260 @default.
• W2110343366 cites W2154699417 @default.
• W2110343366 cites W2161057248 @default.
• W2110343366 cites W2164965999 @default.
• W2110343366 cites W2168784022 @default.
• W2110343366 cites W2371948111 @default.
• W2110343366 doi "https://doi.org/10.1681/asn.2014020195" @default.
• W2110343366 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4378108" @default.
• W2110343366 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25266072" @default.
• W2110343366 hasPublicationYear "2015" @default.
• W2110343366 type Work @default.
• W2110343366 sameAs 2110343366 @default.
• W2110343366 citedByCount "76" @default.
• W2110343366 countsByYear W21103433662015 @default.
• W2110343366 countsByYear W21103433662016 @default.
• W2110343366 countsByYear W21103433662017 @default.
• W2110343366 countsByYear W21103433662018 @default.
• W2110343366 countsByYear W21103433662019 @default.
• W2110343366 countsByYear W21103433662020 @default.
• W2110343366 countsByYear W21103433662021 @default.
• W2110343366 countsByYear W21103433662022 @default.
• W2110343366 countsByYear W21103433662023 @default.
• W2110343366 crossrefType "journal-article" @default.
• W2110343366 hasAuthorship W2110343366A5013589171 @default.
• W2110343366 hasAuthorship W2110343366A5020537311 @default.
• W2110343366 hasAuthorship W2110343366A5024728176 @default.
• W2110343366 hasAuthorship W2110343366A5025609918 @default.
• W2110343366 hasAuthorship W2110343366A5047849518 @default.
• W2110343366 hasAuthorship W2110343366A5054900805 @default.
• W2110343366 hasAuthorship W2110343366A5063904443 @default.
• W2110343366 hasAuthorship W2110343366A5070494006 @default.
• W2110343366 hasAuthorship W2110343366A5078591745 @default.
• W2110343366 hasAuthorship W2110343366A5078790639 @default.
• W2110343366 hasAuthorship W2110343366A5088787939 @default.
• W2110343366 hasBestOaLocation W21103433661 @default.
• W2110343366 hasConcept C121332964 @default.
• W2110343366 hasConcept C123012128 @default.
• W2110343366 hasConcept C126322002 @default.
• W2110343366 hasConcept C134018914 @default.
• W2110343366 hasConcept C142724271 @default.
• W2110343366 hasConcept C153400128 @default.
• W2110343366 hasConcept C16224149 @default.

• next